Neal G. Copeland
Houston Methodist Hospital
730 Papers
12.8K Citations
Neal G. Copeland is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 154, co-authored 726 publications. Previous affiliations of Neal G. Copeland include University of Texas MD Anderson Cancer Center & Boston Children's Hospital.
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Papers
The genomic structure of an insertional mutation in the dystonia musculorum locus.
Arthur Brown,Arthur Brown,Neal G. Copeland,Debra J. Gilbert,Nancy A. Jenkins,Janet Rossant,Janet Rossant,Rashmi Kothary +7 more
TL;DR: It is reported that the integration of the transgene was accompanied by a deletion of 45 kb of host genomic sequences with no other detectable rearrangement in the Tg4 genome.
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Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2.
Peter J. M. Valk,Yolanda Vankan,Marieke Joosten,Nancy A. Jenkins,Neal G. Copeland,Bob Löwenberg,Ruud Delwel +6 more
TL;DR: It is shown that Cnr2 is a frequent target for insertion of Cas-Br-M murine leukemia virus (MuLV) in primary tumors in NIH/Swiss mice, and multiple provirus insertions in Evi11 were cloned and shown to be located within the 3′ untranslated region of the candidate proto-oncogene Cnr 2.
Molecular Cloning and Characterization of Lysosomal Sialic Acid O-Acetylesterase
M. Jorge Guimarães,J. Fernando Bazan,Janice Castagnola,Sandra Diaz,Neal G. Copeland,Debra J. Gilbert,Nancy A. Jenkins,Ajit Varki,Albert Zlotnik +8 more
TL;DR: This constitutes the first report on the molecular cloning of a sialic acid-specific O-acetylesterase in vertebrates and suggests novel roles for the 9-O-acetyl modification of sIALic acids during the development and differentiation of mammalian organisms.
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Genomic Organization and Chromosomal Location of the Mouse Type I BMP-2/4 Receptor
Yuji Mishina,Atsushi Suzuki,Debra J. Gilbert,Neal G. Copeland,Nancy A. Jenkins,Naoto Ueno,Richard R. Behringer +6 more
TL;DR: The structure of a mouse bone morphogenetic protein (BMP) type I receptor gene that can bind both B MP-2 and BMP-4 is characterized and knowledge of the genomic structure of Bmpr provides important information to create BmPR-deficient mice.
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Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals.
TL;DR: It is indicated that the murine genes were probably generated by duplication of a C. elegans-like ancestral gene, but that significant changes have occurred in the genomic organization of either the C. aristans or murine NFI genes during evolution.