Naz Taskin

TL;DR: The morphoelectric properties of homologous mouse and human neocortical GABAergic neuron types are compared to human types and it is found that human types are more excitable and have a larger spatial extent with less neurite branching.

TL;DR: CAP-Mac is shown to have potential for non-invasive systemic gene transfer in the brains of non-human primates and applications of a single, intravenous dose of CAP-Mac to deliver functional GCaMP for ex vivo calcium imaging across multiple brain areas, or a cocktail of fluorescent reporters for Brainbow-like labelling throughout the macaque brain, circumventing the need for germline manipulations.

TL;DR: In this paper , the authors have evolved adeno-associated virus (AAV9) capsids into vectors that transduce brain endothelial cells specifically and efficiently following systemic administration in wild-type mice with diverse genetic backgrounds and rats.

TL;DR: A single-cell multiomics analysis of over 200,000 cells of the primary motor cortex of human, macaque, marmoset and mouse shows that divergence of transcription factor expression corresponds to species-specific epigenome landscapes, and conserved and divergent gene regulatory features are reflected in the evolution of the three-dimensional genome.