Nathaniel Stanley
Barcelona Biomedical Research Park
8 Papers
59 Citations
Nathaniel Stanley is an academic researcher from Barcelona Biomedical Research Park. The author has contributed to research in topics: Glycosylation & Membrane lipids. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Nathaniel Stanley include Pompeu Fabra University & Stanford University.
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Papers
Progress in studying intrinsically disordered proteins with atomistic simulations.
TL;DR: This review presents recent works that highlight the power and potential of atomistic simulations to transform the investigatory pipeline by providing critical insights into the behavior and interactions of intrinsically disordered proteins.
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Computationally Discovered Potentiating Role of Glycans on NMDA Receptors.
Anton V. Sinitskiy,Nathaniel Stanley,David H. Hackos,Jesse E. Hanson,Benjamin D. Sellers,Vijay S. Pande +5 more
TL;DR: The results suggest an intramolecular potentiating role of glycans on NMDA receptors, and predict that glycans at GluN1-N440 might play a potentiator role in NMDARs.
•Posted Content
Computationally Discovered Potentiating Role of Glycans on NMDA Receptors
Anton V. Sinitskiy,Nathaniel Stanley,David H. Hackos,Jesse E. Hanson,Benjamin D. Sellers,Vijay S. Pande +5 more
TL;DR: In this paper, the effects of glycosylation on the structure and dynamics of NMDARs are investigated using extensive molecular dynamics simulations of ligand binding domains (LBDs) to investigate these effects.
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High throughput molecular dynamics for drug discovery
Nathaniel Stanley,Gianni De Fabritiis,Gianni De Fabritiis +2 more
- 13 Feb 2015
TL;DR: Advances in Markov state modeling are outlined here and numerous recent studies that demonstrate that molecular dynamics simulations will start to be an important tool for pharmaceutical research are discussed.
Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH
Enrico Dainese,Gianni De Fabritiis,Annalaura Sabatucci,Sergio Oddi,Clotilde B. Angelucci,Chiara Di Pancrazio,Toni Giorgino,Nathaniel Stanley,Michele Del Carlo,Benjamin F. Cravatt,Mauro Maccarrone +10 more
TL;DR: It is reported that the FAAH dimer is stabilized by the lipid bilayer and shows a higher membrane-binding affinity and enzymatic activity within membranes containing both cholesterol and the natural FAAH substrate AEA (anandamide).