Nathan W. Zammit
Garvan Institute of Medical Research
23 Papers
106 Citations
Nathan W. Zammit is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Transplantation & Islet. The author has an hindex of 9, co-authored 18 publications. Previous affiliations of Nathan W. Zammit include University of New South Wales.
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Papers
Human islets express a marked proinflammatory molecular signature prior to transplantation.
Mark J. Cowley,Anita Weinberg,Nathan W. Zammit,Stacey N. Walters,Wayne J. Hawthorne,Thomas Loudovaris,Helen E. Thomas,Thomas W.H. Kay,Jenny E. Gunton,Stephen I. Alexander,Warren Kaplan,Jeremy R. Chapman,Philip J. O'Connell,Shane T. Grey +13 more
TL;DR: isolated human islets can make cell autonomous contributions to the ensuing allograft response by elaborating inflammatory factors that contribute to their own demise, highlighting the potential importance of islet intrinsic proinflammatory responses as targets for therapeutic intervention.
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Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.
Nathan W. Zammit,Nathan W. Zammit,Owen M. Siggs,Owen M. Siggs,Paul Gray,Keisuke Horikawa,David B. Langley,David B. Langley,Stacey N. Walters,Stacey N. Walters,Stephen R. Daley,Stephen R. Daley,Claudia Loetsch,Joanna Warren,Joanna Warren,Jin Yan Yap,Daniele Cultrone,Daniele Cultrone,Amanda J. Russell,Elisabeth K. Malle,Jeanette E. Villanueva,Mark J. Cowley,Mark J. Cowley,Velimir Gayevskiy,Marcel E. Dinger,Marcel E. Dinger,Robert Brink,Robert Brink,David Zahra,David Zahra,Geeta Chaudhri,Gunasegaran Karupiah,Gunasegaran Karupiah,Belinda Whittle,Carla M. Roots,Edward M. Bertram,Michiko Yamada,Yogesh Jeelall,Anselm Enders,Benjamin E. Clifton,Peter D. Mabbitt,Colin J. Jackson,Susan R. Watson,Craig N. Jenne,Craig N. Jenne,Lewis L. Lanier,Tim Wiltshire,Matthew H. Spitzer,Matthew H. Spitzer,Garry P. Nolan,Frank Schmitz,Frank Schmitz,Alan Aderem,Benjamin T. Porebski,Ashley M. Buckle,Derek W. Abbott,John B. Ziegler,Maria E. Craig,Maria E. Craig,Paul Z. Benitez-Aguirre,Juliana Teo,Stuart G. Tangye,Stuart G. Tangye,Cecile King,Cecile King,Melanie Wong,Murray P. Cox,Wilson Phung,Jia Tang,Wendy Sandoval,Ingrid E. Wertz,Daniel Christ,Daniel Christ,Christopher C. Goodnow,Christopher C. Goodnow,Shane T. Grey,Shane T. Grey +76 more
TL;DR: Genetic analyses of anatomically modern humans, extinct Denisovan hominins and mice revealed a TNFAIP3 allelic series with alterations in the encoded immune response inhibitor A20, which lower A20 activity and increase autoinflammatory responses.
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Nuclear factor κB–inducing kinase activation as a mechanism of pancreatic β cell failure in obesity
Elisabeth K. Malle,Nathan W. Zammit,Stacey N. Walters,Yen Chin Koay,Jianmin Wu,Bernice M. Tan,Jeanette E. Villanueva,Robert Brink,Thomas Loudovaris,James Cantley,Shelli R. McAlpine,Daniel Hesselson,Shane T. Grey +12 more
TL;DR: These studies reveal that NIK contributes a central mechanism for β cell failure in obesity.
β Cell Replacement Therapy: The Next 10 Years.
Christian Schuetz,Takayuki Anazawa,S E Cross,Leticia Labriola,Raphael P. H. Meier,Robert R. Redfield,Hanne Scholz,Peter G. Stock,Nathan W. Zammit +8 more
TL;DR: An international group of young investigators debated which modality of &bgr; cell replacement would predominate the landscape in 10 years, and their arguments are summarized here.
TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation
Nathan W. Zammit,J. McDowell,Joanna Warren,Walter Muskovic,Joanne Gamble,Yan Shi,Dominik C. Kaczorowski,Chia Ling Chan,Joseph E. Powell,Christopher J. Ormandy,David Brown,Samantha R. Oakes,Shane T. Grey +12 more
TL;DR: It is shown that mice harbouring a mild Tnfaip3 reduction-of-function coding variant that reduces the threshold for inflammatory NF-κB activation, exhibit reduced fecundity, highlighting that tuning-up immunity with TNFAIP3 comes with the potentially evolutionary significant trade-off of reduced fertility.