Nathan Qi
University of Michigan
55 Papers
239 Citations
Nathan Qi is an academic researcher from University of Michigan. The author has contributed to research in topics: Insulin resistance & Medicine. The author has an hindex of 24, co-authored 48 publications. Previous affiliations of Nathan Qi include University of California, San Francisco.
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Papers
The protein kinase IKKepsilon regulates energy balance in obese mice
Shian Huey Chiang,Merlijn Bazuine,Carey N. Lumeng,Lynn M. Geletka,Jonathan Mowers,Nicole M. White,Jing Tyan Ma,Jing Tyan Ma,Jie Zhou,Nathan Qi,Daniel J. Westcott,Jennifer B. DelProposto,Timothy S. Blackwell,Fiona E. Yull,Alan R. Saltiel +14 more
TL;DR: Gene expression analyses indicate that IKKepsilon knockout reduces expression of inflammatory cytokines, and changes expression of certain regulatory proteins and enzymes involved in glucose and lipid metabolism, which may represent an attractive therapeutic target for obesity, insulin resistance, diabetes, and other complications associated with these disorders.
352
Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications
Kelli M. Sas,Pradeep P. Kayampilly,Jaeman Byun,Viji Nair,Lucy M. Hinder,Junguk Hur,Hongyu Zhang,Cheng-mao Lin,Nathan Qi,George Michailidis,Per-Henrik Groop,Robert G. Nelson,Manjula Darshi,Kumar Sharma,Jeffrey R. Schelling,John R. Sedor,Rodica Pop-Busui,Joel M. Weinberg,Scott A. Soleimanpour,Steven F. Abcouwer,Thomas W. Gardner,Charles F. Burant,Eva L. Feldman,Matthias Kretzler,Frank C. Brosius,Subramaniam Pennathur +25 more
TL;DR: Tissue-specific changes in metabolism in complication-prone tissues in diabetes are highlighted and it is suggested that urinary TCA cycle intermediates are potential prognostic biomarkers of diabetic kidney disease progression.
Maximal oxidative capacity during exercise is associated with skeletal muscle fuel selection and dynamic changes in mitochondrial protein acetylation.
Katherine A. Overmyer,Charles R. Evans,Nathan Qi,Catherine E. Minogue,Joshua J. Carson,Christopher J. Chermside-Scabbo,Lauren G. Koch,Steven L. Britton,David J. Pagliarini,Joshua J. Coon,Charles F. Burant +10 more
TL;DR: Using metabolomic and proteomic profiling, it is shown that HCR efficiently oxidize fatty acids and branched-chain amino acids, sparing glycogen and reducing accumulation of short- and medium-chain acylcarnitines.
193
Intrinsic Aerobic Capacity Sets a Divide for Aging and Longevity
Lauren G. Koch,Ole J. Kemi,Nathan Qi,Sean X. Leng,Piter Bijma,Lori J. Gilligan,John E. Wilkinson,Helene Wisløff,Morten A. Høydal,Natale Rolim,Peter M. Abadir,Elizabeth M. van Grevenhof,Godfrey L. Smith,Charles F. Burant,Øyvind Ellingsen,Steven L. Britton,Ulrik Wisløff +16 more
TL;DR: Data obtained from a contrasting heterogeneous model system provide strong evidence that genetic segregation for aerobic exercise capacity can be linked with longevity and are useful for deeper mechanistic exploration of aging.
189
NAMPT-Mediated NAD+ Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice
Kelly L Stromsdorfer,Shintaro Yamaguchi,Myeong Jin Yoon,Anna C. Moseley,Michael P Franczyk,Shannon C. Kelly,Nathan Qi,Shin-ichiro Imai,Jun Yoshino +8 more
TL;DR: It is found that adipocyte-specific Nampt knockout mice had severe insulin resistance in adipose tissue, liver, and skeletal muscle and adiposes tissue dysfunction, manifested by increased plasma free fatty acid concentrations and decreased plasma concentrations of a major insulin-sensitizing adipokine, adiponectin.
184