Nathan D. Ide
Pfizer
10 Papers
35 Citations
Nathan D. Ide is an academic researcher from Pfizer. The author has contributed to research in topics: Catalysis & Heck reaction. The author has an hindex of 6, co-authored 10 publications.
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Papers
Palbociclib Commercial Manufacturing Process Development. Part I: Control of Regioselectivity in a Grignard-Mediated SNAr Coupling
Shengquan Duan,David Place,Hahdi H. Perfect,Nathan D. Ide,Mark T. Maloney,Karen Sutherland,Wiglesworth Kristin,Ke Wang,Mark Olivier,Fangming Kong,Kyle R. Leeman,Jon Blunt,John Draper,Marie McAuliffe,Maria M. O’Sullivan,Denis Lynch +15 more
TL;DR: In this paper, the SNAr coupling between aminopyridine 3 and chloropyrimidine 7 was studied from a synthetic and mechanistic perspective, and Grignard bases were identified as the preferred class of bases for this reaction.
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Development of a Practical and Convergent Process for the Preparation of Sulopenem
Steven J. Brenek,Stephane Caron,Esmort Chisowa,Mark P. Delude,Michele T. Drexler,Marcus Ewing,Handfield Robert Eugene,Nathan D. Ide,Durgesh V. Nadkarni,Jade D. Nelson,Mark Olivier,Hahdi H. Perfect,James E. Phillips,John J. Teixeira,R. Matt Weekly,John P. Zelina +15 more
TL;DR: In this paper, a convergent process for the large-scale preparation of sulopenem was proposed, where cyclization of an oxalimide intermediate was used to provide the thiopenem core.
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Synthesis of Filibuvir. Part III. Development of a Process for the Reductive Coupling of an Aldehyde and a β-Keto-lactone
Nathan D. Ide,John A. Ragan,Gabriel Bellavance,Steve J. Brenek,Eric M. Cordi,Grace O. Jensen,Kris N. Jones,Danny Lafrance,Kyle R. Leeman,Leo Joseph Letendre,David Place,Corey L. Stanchina,Gregory W. Sluggett,Holly Strohmeyer,Jon Blunt,Kevin Meldrum,Stuart Taylor,Ciaran Byrne,Denis Lynch,Sandra Mullane,Maria M. O’Sullivan,Marcella Whelan +21 more
TL;DR: In this article, a reductive coupling of a β-keto-lactone and an aldehyde is described, in which the Hantzsch ester serves as an inexpensive and convenient reducing agent.
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Development of a Practical and Efficient Synthesis of Chloromethyl 2-Ethoxy-2-methylpropanoate
John A. Ragan,Nathan D. Ide,Weiling Cai,Cawley James Joseph,Roberto Colon-Cruz,Rajesh Kumar,Zhihui Peng,Brian C. Vanderplas +7 more
TL;DR: In this paper, an efficient synthesis of chloromethyl 2-ethoxy-2-methylpropanoate from 2-bromoisobutyric acid is reported.
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