Natalie Weed
Allen Institute for Brain Science
14 Papers
Natalie Weed is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 4, co-authored 5 publications.
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Papers
Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex
John K. Mich,Lucas T. Graybuck,Hess Erik,Joseph T. Mahoney,Yoshiko Kojima,Yi Ding,Saroja Somasundaram,Jeremy A. Miller,Brian E. Kalmbach,Brian E. Kalmbach,Cristina Radaelli,Bryan B. Gore,Natalie Weed,Victoria Omstead,Yemeserach Bishaw,Nadiya V. Shapovalova,Refugio A. Martinez,Olivia Fong,Shenqin Yao,Marty Mortrud,Peter Chong,Luke Loftus,Darren Bertagnolli,Jeff Goldy,Tamara Casper,Nick Dee,Ximena Opitz-Araya,Ali Cetin,Kimberly A. Smith,Ryder P. Gwinn,Charles Cobbs,Andrew L. Ko,Andrew L. Ko,Jeffrey G. Ojemann,Jeffrey G. Ojemann,C. Dirk Keene,Daniel L. Silbergeld,Susan M. Sunkin,Viviana Gradinaru,Gregory D. Horwitz,Hongkui Zeng,Bosiljka Tasic,Ed S. Lein,Ed S. Lein,Ed S. Lein,Jonathan T. Ting,Jonathan T. Ting,Boaz P. Levi +47 more
TL;DR: In this paper, comparative open chromatin analysis was used to identify thousands of human-neocortical-subclass-specific putative enhancers from across the genome to control gene expression in adeno-associated virus (AAV) vectors.
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Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex
John K. Mich,Lucas T. Graybuck,Hess Erik,Joseph T. Mahoney,Yoshiko Kojima,Yi Ding,Saroja Somasundaram,Jeremy A. Miller,Natalie Weed,Victoria Omstead,Yemeserach Bishaw,Nadiya V. Shapovalova,Refugio A. Martinez,Olivia Fong,Shenqin Yao,Marty Mortrud,Peter Chong,Luke Loftus,Darren Bertagnolli,Jeff Goldy,Tamara Casper,Nick Dee,Ximena Opitz-Araya,Ali Cetin,Kimberly A. Smith,Ryder P. Gwinn,Charles Cobbs,Andrew L. Ko,Jeffrey G. Ojemann,Jeffrey G. Ojemann,C. Dirk Keene,Daniel L. Silbergeld,Susan M. Sunkin,Viviana Gradinaru,Gregory D. Horwitz,Hongkui Zeng,Bosiljka Tasic,Ed S. Lein,Jonathan T. Ting,Boaz P. Levi +39 more
TL;DR: Comparative epigenetics is used to identify thousands of human neuronal subclass-specific putative enhancers to regulate viral tools, and 34% of these were conserved in mouse, and could yield brain-wide specificity greater than the most selective marker genes.
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Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex
Brian Lee,Rachel A. Dalley,Jeremy A. Miller,Thomas Chartrand,Jennie Close,Rusty Mann,Alice Mukora,Lindsay Ng,Lauren Alfiler,Katherine Baker,Darren Bertagnolli,Krissy Brouner,Tamara Casper,Eva Csajbok,Nicholas Donadio,Stan L.W. Driessens,Tom Egdorf,Rachel Enstrom,Anna A. Galakhova,Amanda Gary,Emily Gelfand,Jeff Goldy,Kris HadleyK. Hadley,Tim S. Heistek,DiJon Hill,W. Hou,Nelson Johansen,Nikolas L. Jorstad,Lisa Kim,Ágnes Katalin Kocsis,Lauren Kruse,Michael Kunst,Gabriela Leon,Brian Long,Matthew Mallory,Michelle Maxwell,Medea McGraw,Delissa A. McMillen,Erica J. Melief,Gábor Molnár,Marty T. Mortrud,Dakota Newman,Julie Nyhus,Ximena Opitz-Araya,A. Ozsvár,Trangthanh Pham,Alice Pom,Lydia Potekhina,Ramkumar Rajanbabu,Augustin Ruiz,Susan M. Sunkin,Ildikó Szöts,Naz Taskin,Bargavi Thyagarajan,Michael Tieu,Jessica Trinh,Sara Catalina Grisales Vargas,David J. Vumbaco,Femke Waleboer,Sarah Walling-Bell,Natalie Weed,Grace Williams,Julia Wilson,Shenqin Yao,Thomas Zhou,Pál Barzó,Trygve E. Bakken,Charles Cobbs,Nick Dee,Richard Ellenbogen,Luke A. Esposito,Manuel Ferreira,Nathan W. Gouwens,Benjamin Grannan,Ryder P. Gwinn,Jason Hauptman,Rebecca D. Hodge,Tim Jarsky,C. Dirk Keene,Andrew L. Ko,Anders Rosendal Korshoej,Boaz P. Levi,Kaare Meier,Jeffrey G. Ojemann,Anoop P. Patel,Jacob Ruzevick,Daniel L. Silbergeld,Kimberly A. Smith,Jens Christian Sørensen,Jack Waters,Hongkui Zeng,Jim Berg,M. Capogna,Natalia A. Goriounova,Brian E. Kalmbach,Christiaan P. J. de Kock,Huibert D. Mansvelder,Staci A. Sorensen,Gábor Tamás,Ed S. Lein,Jonathan T. Ting +100 more
TL;DR: The morphoelectric properties of homologous mouse and human neocortical GABAergic neuron types are compared to human types and it is found that human types are more excitable and have a larger spatial extent with less neurite branching.
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Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain.
Miguel R. Chuapoco,Nicholas C. Flytzanis,Nick Goeden,K. M. Roxas,Ken Y. Chan,Jon Scherrer,Janet Winchester,Roy J. Blackburn,Lillian Campos,Kwun Nok Mimi Man,Junqing Sun,Xinhong Chen,Vikram Singh,Cynthia Mary Arokiaraj,Timothy F. Shay,Julia Vendemiatti,Min Jee Jang,John K. Mich,Yemeserach Bishaw,Bryan B. Gore,Victoria Omstead,Naz Taskin,Natalie Weed,Boaz P. Levi,Jonathan T. Ting,Cory T. Miller,Benjamin E. Deverman,James Pickel,Lin Tian,Andrew S. Fox,Viviana Gradinaru +30 more
TL;DR: CAP-Mac is shown to have potential for non-invasive systemic gene transfer in the brains of non-human primates and applications of a single, intravenous dose of CAP-Mac to deliver functional GCaMP for ex vivo calcium imaging across multiple brain areas, or a cocktail of fluorescent reporters for Brainbow-like labelling throughout the macaque brain, circumventing the need for germline manipulations.
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Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
Xinhong Chen,Damien Wolfe,Dhanesh Sivadasan Bindu,Mengying Zhang,Naz Taskin,David Goertsen,Timothy F. Shay,Erin E. Sullivan,Sheng-Fu Huang,Sripriya Ravindra Kumar,Cynthia Mary Arokiaraj,Viktor Plattner,Lillian Campos,John K. Mich,Deja Monet,Victoria Ngo,Xiaozhe Ding,Victoria Omstead,Natalie Weed,Yemeserach Bishaw,Bryan B. Gore,Ed S. Lein,Athena Akrami,Cory T. Miller,Boaz P. Levi,Annika Keller,Jonathan T. Ting,Andrew S. Fox,Cagla Eroglu,Viviana Gradinaru +29 more
TL;DR: In this paper , the authors have evolved adeno-associated virus (AAV9) capsids into vectors that transduce brain endothelial cells specifically and efficiently following systemic administration in wild-type mice with diverse genetic backgrounds and rats.