Natalie Ring
University of Bath
16 Papers
41 Citations
Natalie Ring is an academic researcher from University of Bath. The author has contributed to research in topics: Bordetella pertussis & Genome. The author has an hindex of 5, co-authored 11 publications. Previous affiliations of Natalie Ring include University of Edinburgh & Medical Research Council.
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Papers
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium
Terrence F. Meehan,Nathalie Conte,David B. West,Julius O.B. Jacobsen,Jeremy Mason,Jonathan Warren,Chao-Kung Chen,Ilinca Tudose,Mike Relac,Peter Matthews,Natasha A. Karp,Luis Santos,Tanja Fiegel,Natalie Ring,Henrik Westerberg,Simon Greenaway,Duncan Sneddon,Hugh P. Morgan,Gemma F. Codner,Michelle Stewart,James M. Brown,Neil R. Horner,Melissa A. Haendel,Nicole L. Washington,Christopher J. Mungall,Corey L. Reynolds,Juan Gallegos,Valerie Gailus-Durner,Tania Sorg,Guillaume Pavlovic,Lynette Bower,Mark W. Moore,Iva Morse,Xiang Gao,Glauco P. Tocchini-Valentini,Yuichi Obata,Soo Young Cho,Je Kyung Seong,John R. Seavitt,Arthur L. Beaudet,Mary E. Dickinson,Yann Herault,Wolfgang Wurst,Martin Hrabé de Angelis,Kevin C K Lloyd,Ann M. Flenniken,Lauryl M. J. Nutter,Susan Newbigging,Colin McKerlie,Monica J. Justice,Stephen A. Murray,Karen L. Svenson,Robert E. Braun,Jacqueline K. White,Allan Bradley,Paul Flicek,Sara Wells,William C. Skarnes,David J. Adams,Helen Parkinson,Ann-Marie Mallon,Stephen D.M. Brown,Damian Smedley +62 more
TL;DR: Analyzing the first 3,328 genes identified models for 360 diseases, including the first models, to the knowledge, for type C Bernard–Soulier, Bardet–Biedl-5 and Gordon Holmes syndromes, and 90% of phenotype annotations were novel, providing functional evidence for 1,092 genes and candidates in genetically uncharacterized diseases.
Resolving the complex Bordetella pertussis genome using barcoded nanopore sequencing.
Natalie Ring,Jonathan S. Abrahams,Miten Jain,Hugh E. Olsen,Andrew Preston,Stefan Bagby +5 more
- 01 Nov 2018
TL;DR: The ability to resolve the structure of several B. pertussis strains per single barcoded nanopore flow cell is demonstrated, but the genomes with highest complexity remain only partially resolved using the standard library preparation and will require an alternative library preparation method.
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Resolving the complex Bordetella pertussis genome using barcoded nanopore sequencing
TL;DR: The ability to resolve the structure of several B. pertussis strains per single barcoded nanopore flow cell is demonstrated, expanding the recently emergent theme that even the most complex genomes can be resolved with sufficiently long sequencing reads.
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How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis.
TL;DR: In this paper, the authors discuss the evolution of Bordetella pertussis, including how vaccination is changing the circulating B.pertussis population at the gene-level, and how new sequencing technologies are revealing previously unknown levels of inter-and intra-strain variation at the genome-level.
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Acapsular Staphylococcus aureus with a non-functional agr regains capsule expression after passage through the bloodstream in a bacteremia mouse model.
Carlos M Suligoy,Rocío E Díaz,Ana-Katharina Gehrke,Natalie Ring,Gonzalo Yebra,Joana Alves,Marisa Ines Gomez,Sindy Wendler,J. Ross Fitzgerald,Lorena Tuchscherr,Bettina Löffler,Daniel O. Sordelli,Mariángeles Noto Llana,Fernanda Roxana Buzzola +13 more
TL;DR: Stable, non-encapsulated S. aureus organisms that escape the infected bone may recover the expression of key virulence factors through a rapid microevolution pathway involving SigB regulation of keyvirulence factors.