Natalie J. Prescott
King's College London
84 Papers
553 Citations
Natalie J. Prescott is an academic researcher from King's College London. The author has contributed to research in topics: Genome-wide association study & Inflammatory bowel disease. The author has an hindex of 40, co-authored 79 publications. Previous affiliations of Natalie J. Prescott include UCL Institute of Child Health & University College London.
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Papers
Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis
Francesca Capon,Paola Di Meglio,Joanna Szaub,Natalie J. Prescott,Christina Dunster,L Baumber,Kirsten Timms,Alexander Gutin,Victor Abkevic,A. David Burden,Jerry S. Lanchbury,Jonathan Barker,Richard C. Trembath,Richard C. Trembath,Frank O. Nestle +14 more
TL;DR: Findings indicate that genes participating in IL23 signalling play a significant role in the pathogenesis of chronic epithelial inflammation.
Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes.
Natalie J. Prescott,Benjamin Lehne,Kristina L. Stone,James Lee,Kirstin M. Taylor,Jo Knight,Efterpi Papouli,Muddassar M. Mirza,Michael A. Simpson,Sarah L. Spain,Grace H C Lu,Franca Fraternali,Suzannah Bumpstead,Emma Gray,Ariella Amar,Hannah Bye,Peter M. Green,Guy Chung-Faye,Bu'Hussain Hayee,Richard Pollok,Jack Satsangi,Miles Parkes,Jeffrey C. Barrett,John C. Mansfield,Jeremy D. Sanderson,Cathryn M. Lewis,Michael E. Weale,Thomas Schlitt,Christopher G. Mathew +28 more
TL;DR: It is suggested that although rare coding variants may make a modest overall contribution to complex disease susceptibility, they can inform the understanding of the molecular pathways that contribute to pathogenesis.
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
Sheila A. Fisher,Mark Tremelling,Carl A. Anderson,Rhian Gwilliam,Suzannah Bumpstead,Natalie J. Prescott,Elaine R. Nimmo,Dunecan Massey,Carlo Berzuini,Chris Johnson,Jeffrey C. Barrett,Fraser Cummings,Hazel E. Drummond,Charlie W. Lees,Clive M. Onnie,Catherine Hanson,Katarzyna Blaszczyk,Michael Inouye,Philip Ewels,Radhi Ravindrarajah,Andrew Keniry,Sarah E. Hunt,M J Carter,Nicholas A. Watkins,Willem H. Ouwehand,Cathryn M. Lewis,Lon R. Cardon,Alan J Lobo,Alastair Forbes,Jeremy D. Sanderson,Derek P. Jewell,John C. Mansfield,Panos Deloukas,Christopher G. Mathew,Miles Parkes,Jack Satsangi +35 more
TL;DR: Results of a nonsynonymous SNP scan for ulcerative colitis and a previously unknown susceptibility locus at ECM1 are reported, providing the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.
Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa.
Hannah Bye,Natalie J. Prescott,Marco Matejcic,Elizabeth F. Rose,Cathryn M. Lewis,M. Iqbal Parker,Christopher G. Mathew +6 more
TL;DR: Several instances of population-specific differences in the genetic etiology of OSCC are indicated between these two South African populations and between them and other high-risk populations, which may reflect differences in their ancestry and environmental exposures.