Natalie Clark
King's College London
6 Papers
16 Citations
Natalie Clark is an academic researcher from King's College London. The author has contributed to research in topics: TRPV1 & Calcitonin gene-related peptide. The author has an hindex of 5, co-authored 6 publications.
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Papers
Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.
Ágnes Bánvölgyi,László Pálinkás,Timea Berki,Natalie Clark,Andrew D. Grant,Zsuzsanna Helyes,Gábor Pozsgai,János Szolcsányi,Susan D. Brain,Erika Pintér +9 more
TL;DR: A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.
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A reactive oxygen species-mediated component in neurogenic vasodilatation
Anna Starr,Rabea Graepel,Julie Keeble,Sabine Schmidhuber,Natalie Clark,Andrew D. Grant,Ajay M. Shah,Susan D. Brain +7 more
TL;DR: In vivo evidence that ROS are involved in mediating TRPV1- and neuropeptide-dependent neurogenic vasodilatation is provided, and an essential role of NADPH oxidase-dependent ROS is revealed that may be of fundamental importance to the neurogenic Vasodilator component involved in circulatory homeostasis and the pathophysiology of certain cardiovascular diseases.
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Protection of Angiotensin II-Induced Vascular Hypertrophy in Vascular Smooth Muscle-Targeted Receptor Activity-Modifying Protein 2 Transgenic Mice
Lihuan Liang,Christina W. Tam,Gábor Pozsgai,Richard C.M. Siow,Natalie Clark,Julie Keeble,Knut Husmann,Walter Born,Jan A. Fischer,Robin Poston,Ajay M. Shah,Susan D. Brain +11 more
TL;DR: The finding that the vascular smooth muscle AM1 receptor acts at a local level to protect against hypertension-induced vascular hypertrophy and inflammation provides evidence that targeting this receptor may be a beneficial therapeutic approach.
17
Enhanced Vascular Responses to Adrenomedullin in Mice Overexpressing Receptor-Activity–Modifying Protein 2
Christina W. Tam,Knut Husmann,Natalie Clark,James Clark,Z. Lazar,Lars M. Ittner,Jürgen Götz,Gillian Douglas,Andrew D. Grant,David Sugden,Lucilla Poston,Robin Poston,Ian McFadzean,Michael S. Marber,Jan A. Fischer,Walter Born,Susan D. Brain +16 more
TL;DR: RAMP2 plays a key role in the sensitivity and potency of AM-induced hypotensive responses via the AM1 receptor, providing evidence that this receptor is a selective target for novel therapeutic approaches.