Natalia Liem
National University of Singapore
11 Papers
91 Citations
Natalia Liem is an academic researcher from National University of Singapore. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 9, co-authored 11 publications. Previous affiliations of Natalia Liem include Kyungpook National University Hospital & University Health System.
Chat about Author
Papers
Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer
Hermioni Zouridis,Niantao Deng,Tatiana Ivanova,Yansong Zhu,Bernice Wong,Dan Huang,Yonghui Wu,Yingting Wu,Iain Beehuat Tan,Natalia Liem,Veena Gopalakrishnan,Qin Luo,Jeanie Wu,Minghui Lee,Wei Peng Yong,Liang Kee Goh,Bin Tean Teh,Bin Tean Teh,Steve Rozen,Steve Rozen,Patrick Tan +20 more
TL;DR: The authors extensively characterized methylation patterns in human gastric cancers, which revealed tumor-specific arrangements of hyper- and hypomethylation and long-range regions of epigenetic silencing (LRESs) in CIMP tumors.
189
Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer
Tatiana Ivanova,Hermioni Zouridis,Yonghui Wu,Lai Ling Cheng,Iain Beehuat Tan,Veena Gopalakrishnan,Chia Huey Ooi,Julian Lee,Luo Qin,Jeanie Wu,Minghui Lee,Sun Young Rha,Dan Huang,Natalia Liem,Khay Guan Yeoh,Wei Peng Yong,Bin Tean Teh,Patrick Tan,Patrick Tan +18 more
TL;DR: Epigenomic analysis identified bone morphogenetic protein 4 (BMP4) as an epigenetically regulated gene highly expressed in cisplatin-resistant lines, and functional assays confirmed that BMP4 is necessary and sufficient for the expression of several prooncogenic traits, likely mediated through stimulation of the epithelial-mesenchymal transition.
135
Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features.
Pei Woon Ang,Pei Woon Ang,Marie Loh,Marie Loh,Natalia Liem,Pei Li Lim,Fabienne Grieu,Aparna Vaithilingam,Cameron Platell,Cameron Platell,Wei Peng Yong,Barry Iacopetta,Richie Soong +12 more
TL;DR: Comprehensive DNA methylation profiling of CRC suggests that both KRAS and BRAF mutations are involved with the CIMP-H pathway of CRC rather than with distinct CimP subgroups.
DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach
Marie Loh,Natalia Liem,Aparna Vaithilingam,Pei Li Lim,Nur Sabrina Sapari,Eiram Elahi,Zuan Yu Mok,Chee Leong Cheng,Benedict Yan,Brendan Pang,Manuel Salto-Tellez,Manuel Salto-Tellez,Manuel Salto-Tellez,Wei Peng Yong,Barry Iacopetta,Richie Soong,Richie Soong +16 more
TL;DR: High-throughput methylation analysis implicates genes involved in embryonic development and hedgehog signaling in gastric tumorigenesis in GC, with the highly methylated group showing some features consistent with a CpG island methylator phenotype.
40
Combination Therapy with Gossypol Reveals Synergism against Gemcitabine Resistance in Cancer Cells with High BCL-2 Expression
Foong Ying Wong,Natalia Liem,Chen Xie,Fui Leng Yan,Wing-Cheong Wong,Lingzhi Wang,Wei Peng Yong,Wei Peng Yong +7 more
TL;DR: Gene expression profiling in G EM-R and GEM-S cell lines suggest that anti-apoptotic genes such as pAkt and PI3KR2 may play important role in gemcitabine resistance, while pro-APoptotic Bcl-2 related genes (Bad, Caspase-6 and Calpain-1) may regulate synergistic interaction in combination therapy.