Narcis Fernandez-Fuentes
Aberystwyth University
100 Papers
251 Citations
Narcis Fernandez-Fuentes is an academic researcher from Aberystwyth University. The author has contributed to research in topics: Biology & Protein structure. The author has an hindex of 25, co-authored 88 publications. Previous affiliations of Narcis Fernandez-Fuentes include University of Leeds & University of Vic.
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Papers
Evolutionary and biophysical relationships among the papillomavirus E2 proteins.
Dukagjin Blakaj,Narcis Fernandez-Fuentes,Zigui Chen,Rashmi S. Hegde,Andras Fiser,Robert D. Burk,Michael Brenowitz +6 more
TL;DR: The biophysical character of this core viral protein is explored with the goal of identifying characteristics that associated with risk of virally caused malignancy and implications to cancer biology are discussed.
Exchanging murine and human immunoglobulin constant chains affects the kinetics and thermodynamics of antigen binding and chimeric antibody autoreactivity
TL;DR: It is suggested that V region conformational changes can be dictated by the CH domains through an allosteric effect involving networks of highly connected amino acids.
Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription.
Priyanka Sharma,Antonios Lioutas,Narcis Fernandez-Fuentes,Javier Quilez,José Carbonell-Caballero,Roni H. G. Wright,Chiara Di Vona,François Le Dily,Roland Schüller,Dirk Eick,Baldomero Oliva,Miguel Beato +11 more
TL;DR: A new modification at the CTD is identified, the deimination of arginine and its conversion to citrulline by peptidylArginine deiminase 2 (PADI2), an enzyme that has been associated with several diseases, including cancer.
Preclinical development of a humanized chimeric antigen receptor against B cell maturation antigen for multiple myeloma.
Lorena Perez-Amill,Guillermo Suñe,Asier Antoñana-Vildosola,Maria Castella,Amer Najjar,Jaume Bonet,Narcis Fernandez-Fuentes,Susana Inogés,Ascensión López,Clara Bueno,Manel Juan,Alvaro Urbano-Ispizua,Beatriz Martín-Antonio +12 more
TL;DR: This study sets the bases for the implementation of a clinical trial to study the efficacy of ARI2h-cell treatment for patients with multiple myeloma, and demonstrated that soluble BCMA and BCMA released in vesicles both affect CAR-BCMA activity.
A Functional Kinase Is Necessary for Cyclin-Dependent Kinase G1 (CDKG1) to Maintain Fertility at High Ambient Temperature in Arabidopsis
Candida Nibau,Despoina Dadarou,Despoina Dadarou,Nestoras Kargios,Areti Mallioura,Narcis Fernandez-Fuentes,Nicola Cavallari,John H. Doonan +7 more
TL;DR: It is shown that the long form is necessary and sufficient to rescue the fertility defects of the cdkg1-1 mutant, while the short form is unable to rescue fertility, and there is partial functional overlap betweenCDKG1 and its paralog CDKG2 that could in part be explained by overlapping gene expression.