Naoaki Sakamoto

TL;DR: A novel DNA structure, sticky DNA, is described for lengths of (GAA.TTC)n found in intron 1 of the frataxin gene of Friedreich's ataxia patients and R.R.Y triplexes and/or sticky DNA may be involved in the etiology of FRDA.

TL;DR: Evidence is presented that mRNAs of HpOtxE/L are transcribed from a single Hp Otx gene by altering the transcription start site and by alternative splicing, and it is demonstrated that H pOtxL activates the Ars promoter in the gastrula-stage embryo.

TL;DR: The update of the draft genome assembly of sea urchin, Hemicentrotus pulcherrimus, which is widely studied in East Asia as a model organism of early development, was performed using Oxford nanopore long-read sequencing to provide further advance for genome-wide research of development, gene regulation, and intranuclear structural dynamics of multicellular organisms.

TL;DR: Researchers developed an automated pain assessment method using convolutional neural networks (CNNs) to analyze facial images of free-moving mice, accurately predicting pain and analgesic effects in various pain models, including acetic acid, capsaicin, and calcitonin gene-related peptide-induced pain.