13 Papers
51 Citations
Nancy Yeh is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cyclin-dependent kinase & Cell cycle. The author has an hindex of 9, co-authored 12 publications.
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Papers
Interweaving the cell cycle machinery with cell differentiation.
TL;DR: Examples from the laboratory are highlighted that provided a broader understanding of the types of roles that cell cycle regulators play during differentiation, beginning with the phenotypes observed in mice.
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Somatic cell type specific gene transfer reveals a tumor‐promoting function for p21Waf1/Cip1
Yuhui Liu,Nancy Yeh,Xin-Hua Zhu,Margaret Leversha,Carlos Cordon-Cardo,Ronald Ghossein,Bhuvanesh Singh,Eric C. Holland,Andrew Koff +8 more
TL;DR: It is demonstrated that the RCAS/TvA system, originally developed to introduce oncogenes into somatic cells of mice, can be adapted to allow for the utility of using a somatic cell modeling system for defining the contribution proteins make to tumor development.
p27kip1 Regulates cdk2 Activity in the Proliferating Zone of the Mouse Intestinal Epithelium: Potential Role in Neoplasia
Helena J M Smartt,Sandra Guilmeau,Shannon Nasser,Courtney Nicholas,Laura Bancroft,Sharon A. Simpson,Nancy Yeh,Wancai Yang,John M. Mariadason,Andrew Koff,Leonard H. Augenlicht +10 more
TL;DR: It is proposed that p27 contributes to intestinal epithelial homeostasis by regulating cdk2 activity in proliferating cells, thus gating cell cycle progression and suppressing intestinal neoplasia.
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p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow.
Anxo Vidal,Anxo Vidal,Stergios Zacharoulis,Stergios Zacharoulis,Wenjun Guo,David R. Shaffer,Filippo G Giancotti,Anna H. Bramley,Carmen de la Hoz,Kristian Jensen,Daniel Kato,Daniel D. MacDonald,Joseph Knowles,Nancy Yeh,Lawrence A. Frohman,Shahin Rafii,David Lyden,Andrew Koff +17 more
TL;DR: It is reported that mice lacking the cell cycle inhibitors p130 and p27 show defects in tumor neoangiogenesis, both in xenografts and spontaneously arising tumors, and it is suggested that cell expansion and mobilization from the bone marrow of angiogenic precursors are separable events.
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Tyrosine Phosphorylation of the p21 Cyclin-dependent Kinase Inhibitor Facilitates the Development of Proneural Glioma
TL;DR: It is concluded that tyrosine phosphorylation contributes to the conversion of CDK inhibitors from tumor-suppressive roles to oncogenic roles.
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