Nancy J. Phillips
University of California, San Francisco
38 Papers
789 Citations
Nancy J. Phillips is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lipid A & Heptose. The author has an hindex of 25, co-authored 36 publications. Previous affiliations of Nancy J. Phillips include University of California & University at Buffalo.
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Papers
Investigation of the structural heterogeneity of lipooligosaccharides from pathogenic Haemophilus and Neisseria species and of R-type lipopolysaccharides from Salmonella typhimurium by electrospray mass spectrometry.
Bradford W. Gibson,William Melaugh,Nancy J. Phillips,Michael A. Apicella,Anthony A. Campagnari,J M Griffiss +5 more
TL;DR: The precise molecular weights of LOS (and LPS) preparations from various Haemophilus, Neisseria, and Salmonella species are determined by electrospray ionization-mass spectrometry to investigate the underlying genetic and environmental factors controlling LOS and LPS expression.
Novel modification of lipid A of Francisella tularensis.
Nancy J. Phillips,Birgit Schilling,Molly K. McLendon,Michael A. Apicella,Bradford W. Gibson,Bradford W. Gibson +5 more
TL;DR: Several of the lipid A components present in strain 1547-57 were of higher molecular weight than the previously published structures, and could potentially influence its intracellular survival by conferring resistance to antimicrobial peptides.
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Structural characterization of the cell surface lipooligosaccharides from a nontypable strain of Haemophilus influenzae.
TL;DR: Mass spectral analyses of O-deacylated LOS and free lipid A confirmed that, in addition to the two phosphoethanolamines on the oligosaccharide and two phosphates on the lipid A, another phosphate group exists on the KDO, which may represent a form of host mimicry by the pathogen.
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Nontypeable Haemophilus influenzae Strain 2019 Produces a Biofilm Containing N-Acetylneuraminic Acid That May Mimic Sialylated O-Linked Glycans
Laura L Greiner,Hiroshi Watanabe,Nancy J. Phillips,Jianqiang Shao,A. Morgan,Anthony Zaleski,Bradford W. Gibson,Michael A. Apicella +7 more
TL;DR: In this paper, a 5-day biofilm of Haemophilus influenzae (NTHI) strain 2019 grown in a continuous flow chamber revealed that the biofilm had a diffuse matrix interlaced with multiple water channels.
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Haemophilus influenzae type b strain A2 has multiple sialyltransferases involved in lipooligosaccharide sialylation.
Paul A. Jones,Nicole M. Samuels,Nancy J. Phillips,Robert S. Munson,Joel A. Bozue,Julie A. Arseneau,Wade A. Nichols,Anthony Zaleski,Bradford W. Gibson,Bradford W. Gibson,Michael A. Apicella +10 more
TL;DR: These results demonstrate that the sialylation of the LOS of H. influenzae is a complex process involving multiple sIALyltransferases.
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