Nancy Grenier
20 Papers
197 Citations
Nancy Grenier is an academic researcher. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 12, co-authored 20 publications.
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Papers
Multipotent mesenchymal stem cell grafting to treat cutaneous radiation syndrome: Development of a new minipig model
Diane Agay,Harry Scherthan,Fabien Forcheron,Nancy Grenier,Francis Herodin,Viktor Meineke,Michel Drouet +6 more
TL;DR: A new minipig model of severe CRS is developed that is close to human and allows development of stem cell therapy strategies that can be applied in treatment of human radiation burns.
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The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, FLT-3 ligand, TPO, and IL-3 in combination resulted in CD34+ cell proliferation and differentiation.
TL;DR: In this article, the early effects of exogenous cytokines at the hematopoietic stem and progenitor cell (HSPC) level following irradiation are still largely unknown, especially those of survival factors such as stem cell factor (SCF) and Flt-3 ligand (FL).
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Antiapoptotic cytokines in combination with pegfilgrastim soon after irradiation mitigates myelosuppression in nonhuman primates exposed to high irradiation dose.
Francis Herodin,Laurence Roy,Nancy Grenier,Christophe Delaunay,Stéphane Baugé,Aurélie Vaurijoux,Eric Gregoire,Cécile Martin,Antonia Alonso,Jean-François Mayol,Michel Drouet +10 more
TL;DR: The results suggest the safety and efficacy of EACK in managing severe radiation exposure and show that a single, intravenous injection of SFT3 2 hours after 7-Gy TBI reduced the period of thrombocytopenia and blood transfusion needs.
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Revisiting therapeutic strategies in radiation casualties
TL;DR: As a potentially multi-organ failure, ARS requires global therapy, beyond the hematopoietic syndrome, which may include pleiotropic cytokines such as KGF, and SFT3 anti-apoptotic cytokine combination administered early after lethal TBI induced 60% survival versus 5% in controls.
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Ex vivo expanded mobilized peripheral blood CD34+ cells accelerate haematological recovery in a baboon model of autologous transplantation.
Françoise Norol,Michel Drouet,Jacques Mathieu,Najet Debili,Hélène Jouault,Nancy Grenier,Agnès Laplanche,William Vainchenker,Francis Herodin +8 more
TL;DR: This study shows that in comparison with unmanipulated cells peripheral blood haematopoietic cells expanded from similar doses of CD34+ cells, under the conditions defined here, accelerated both neutrophil and platelet recovery without impairing long‐term haem atopoiesis.
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