BACKGROUND
Oxheart cabbage (Brassica oleracea var. capitata) is a member of the Brassica genus. Although some studies on the anticancer effects of extracts from oxheart cabbage have been reported, comprehensive information on the bioactive fractions and components from oxheart cabbage extracts is still lacking. The aim of this study was to isolate and identify the bioactive fractions and components from oxheart cabbage seeds using activity-guided isolation methods.

RESULTS
The cytotoxicity and apoptotic effects of fraction II, fraction III, iberverin, sulforaphane and iberin from oxheart cabbage seed extract were investigated. The results showed that all five components had inhibitory effects on the in vitro growth of A549 cells which were dose-dependent. These compounds also changed the morphology of A549 cells, and their inhibitory activity on A549 cells was as follows: sulforaphane > iberin > iberverin > fraction III > fraction II. The IC50 values were 3.53 ± 0.63, 4.93 ± 1.02, 7.07 ± 0.51, 15.56 ± 0.24 and 27.32 ± 0.63 µg mL−1 respectively. Fraction II, fraction III, iberverin, sulforaphane and iberin induced cell apoptosis by increasing early apoptosis and late apoptosis/necrosis, and activation of caspase-3, −8 and −9.

CONCLUSION
These results indicated that the decrease in A549 cell viability by active compounds from oxheart cabbage seed extract was due to the induction of apoptosis. © 2015 Society of Chemical Industry

Inhibition of growth and induction of apoptosis in A549 cells by compounds from oxheart cabbage extract.

The inhibition activity to human lung cancer cells A549 of five ITCs were tested by MTT. The relationships between the electronic structure and anticancer activity were analyzed by the parameters of the geometry, Mulliken populations and the atomic frontier electron densities, which were optimized by DMol3 module. The results showed that carbon atom of the ITCs in the group of N=C=S was the main electrophonic reaction site, and sulfonyl or sulfur in the side chain was the secondary site. The analysis proved that the anticancer activities of ITCs were relative to the negative charge populations, delocalization of frontier molecular orbital and the energy gaps of HOMO-LUMO.

Study on the relationships between anticancer activities of ITCs and its structure

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Study on the relationships between anticancer activities of ITCs and its structure