36 Papers
29 Citations
Nan Si is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Arenobufagin & Chemistry. The author has an hindex of 13, co-authored 36 publications. Previous affiliations of Nan Si include Tokyo University of Pharmacy and Life Sciences.
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Papers
Chemical profiling of the Chinese herb formula Xiao-Cheng-Qi Decoction using liquid chromatography coupled with electrospray ionization mass spectrometry.
TL;DR: The characteristic fragmentation pathways of 17 reference compounds were comprehensively studied, including precursors of tannins, flavonones, anthraquinones and lignan, and 71 constituents were identified or tentatively characterized based on their mass spectrometry fragmentations and chromatographic behaviors.
Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer's disease progression based on the "brain-gut" axis through multiple integrated omics.
Xinru Gu,Junyi Zhou,Yanyan Zhou,Hongjie Wang,Nan Si,Wei Ren,Wei Zhao,Xiaorui Fan,Gao W,Xiaolu Wei,Jian Yang,Baolin Bian,Hai-Yu Zhao +12 more
TL;DR: Huang et al. as discussed by the authors provided a potential link between the central and peripheral neuroinflammatory disorders in AD progression The Morris water maze (MWM) test, immunohistochemistry, ELISA, ProcartaPlex Multiplex immunoassay, multiple LC-MS/MS methods, and the V3-V4 regions of 16S rRNA genes were applied to explore potential biomarkers In Tg-APP/PS1 mice, gut dysbiosis and lipid metabolism were highly associated with AD-like neuroinflammation.
Effects of active bufadienolide compounds on human cancer cells and CD4+CD25+Foxp3+ regulatory T cells in mitogen-activated human peripheral blood mononuclear cells.
Bo Yuan,Jing He,Keishi Kisoh,Hideki Hayashi,Sachiko Tanaka,Nan Si,Haiyu Zhao,Toshihiko Hirano,Baolin Bian,Norio Takagi +9 more
TL;DR: Investigation of the growth inhibitory effects of bufadienolide compounds in intractable cancer cells suggests that gamabufotalin may serve as a promising candidate, as an adjuvant therapeutic agent by manipulating Treg cells to enhance the efficacy of conventional anticancer drugs and lessen their side-effects.
Pharmacokinetic-Pharmacodynamic Analysis on Inflammation Rat Model after Oral Administration of Huang Lian Jie Du Decoction
Wei Ren,Wei Ren,Ran Zuo,Yao-Nan Wang,Hongjie Wang,Jian Yang,Shao-Kun Xin,Shao-Kun Xin,Lingyu Han,Haiyu Zhao,Shu-Yan Han,Bo Gao,Hao Hu,Yuanjia Hu,Baolin Bian,Nan Si +15 more
TL;DR: It is demonstrated that HLJDD may restrain inflammation synergistically via its major constituents (alkaloids, flavonoids and iridoids) through its three-phase synchronous characterization of time-concentration-effect.
Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry and HPLC-photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections.
TL;DR: A feasible strategy integrated markers screening, determination, and statistical analysis was efficiently proposed, especially for the undefined Chinese medicine injections, and provides a newly feasible solution for the quality control of Chinese Medicine injections.
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