Nan Liu
Chinese Academy of Sciences
35 Papers
264 Citations
Nan Liu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 15, co-authored 33 publications. Previous affiliations of Nan Liu include Tsinghua University & Huazhong Agricultural University.
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Papers
The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila
Nan Liu,Michael Landreh,Michael Landreh,Kajia Cao,Masashi Abe,Gert-Jan Hendriks,Jason R. Kennerdell,Yongqing Zhu,Li-San Wang,Nancy M. Bonini,Nancy M. Bonini +10 more
TL;DR: It is reported that the conserved miRNA miR-34 regulates age-associated events and long-term brain integrity in Drosophila, providing a molecular link between ageing and neurodegeneration.
Metabolic reaction network-based recursive metabolite annotation for untargeted metabolomics.
Xiaotao Shen,Ruohong Wang,Xin Xiong,Yandong Yin,Yuping Cai,Zaijun Ma,Nan Liu,Zheng-Jiang Zhu +7 more
TL;DR: A metabolic reaction network-based recursive algorithm that expands metabolite annotation by taking advantage of the mass spectral similarity of reaction-paired neighbor metabolites is developed.
MicroRNA pathways modulate polyglutamine-induced neurodegeneration.
Julide Bilen,Nan Liu,Barrington G. Burnett,Randall N. Pittman,Nancy M. Bonini,Nancy M. Bonini +5 more
TL;DR: Findings indicate that miRNA pathways dramatically modulate polyQ- and tau-induced neurodegeneration, providing the foundation for new insight into therapeutics.
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Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression.
Kezhou Zhu,Wei Liang,Zaijun Ma,Daichao Xu,Shuangyi Cao,Xiaojuan Lu,Nan Liu,Bing Shan,Lihui Qian,Junying Yuan,Junying Yuan +10 more
TL;DR: It is concluded that TNFα-induced necroptosis signaling events mediated by RIPK1 and RIPK3 activation, in addition to the MLKL oligomerization, promotes the expression of cytokines involving multiple intracellular signaling mechanisms including NF-κB pathway and p38.
The exoribonuclease Nibbler controls 3' end processing of microRNAs in Drosophila.
Nan Liu,Masashi Abe,Leah R. Sabin,Gert-Jan Hendriks,Ammar S. Naqvi,Zhenming Yu,Sara Cherry,Nancy M. Bonini +7 more
TL;DR: Deep sequencing analysis revealed a larger set of multi-isoform miRNAs that are controlled by nibbler, suggesting that Nbr-mediated 3' end processing represents a critical step in miRNA maturation that impacts miRNA diversity.
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