Nan Jin
Chinese Academy of Sciences
12 Papers
11 Citations
Nan Jin is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Cancer & Phosphoglycerate Mutase 1. The author has an hindex of 6, co-authored 11 publications. Previous affiliations of Nan Jin include University of California, San Francisco.
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Papers
Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer
Hanlin Zeng,Jia Qu,Nan Jin,Jun Xu,Chenchu Lin,Yi Chen,Xinying Yang,Xiang He,Shuai Tang,Lan Xiaojing,Xiao-Tong Yang,Ziqi Chen,Min Huang,Jian Ding,Meiyu Geng +14 more
TL;DR: It is discovered that feedback activation of leukemia inhibitory factor receptor (LIFR) signaling in breast cancer limits the response to HDAC inhibition, implicating combination inhibition of HDAC with JAK1 or BRD4 as potential therapies for breast cancer.
144
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
Nan Jin,Aiwei Bi,Lan Xiaojing,Jun Xu,Xiaomin Wang,Yingluo Liu,Ting Wang,Shuai Tang,Hanlin Zeng,Ziqi Chen,Minjia Tan,Jing Ai,Hua Xie,Tao Zhang,Dandan Liu,Ruimin Huang,Yue Song,Elaine Lai-Han Leung,Xiao-Jun Yao,Jian Ding,Meiyu Geng,Shuhai Lin,Min Huang +22 more
TL;DR: The authors show that in lung cancer, genetic activation of distinct oncogenic receptor tyrosine kinases results in unique metabolic liabilities and, in particular, EGFR aberrant cancers rely on the serine biosynthetic pathway while FGFR aberrants cancers reliance on glycolysis.
Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity.
Di Zhang,Nan Jin,Wei Sun,Xia Li,Bo Liu,Zuoquan Xie,Jia Qu,Jiangshan Xu,Xinying Yang,Yi Su,Shuang Tang,H Han,Dong-Ying Chen,Jian Ding,Minjia Tan,Min Huang,Meiyu Geng +16 more
TL;DR: This study provided the first evidence revealing a non-metabolic function of PGAM1 in promoting cell migration, and gained new insights into the role of PG AM1 in cancer progression.
88
JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification
Wenyi Sun,Zuoquan Xie,Liu Yifu,Dan Zhao,Zhixiang Wu,Dadong Zhang,Hao Lv,Shuai Tang,Nan Jin,Hualiang Jiang,Minjia Tan,Jian Ding,Cheng Luo,Jian Li,Min Huang,Meiyu Geng +15 more
TL;DR: Investigations of JX06 mechanism suggested that covalent modification at C240 induced conformational changes at Arginine 286 through Van der Waals forces, thereby hindering access of ATP to its binding pocket and in turn impairing PDK1 enzymatic activity, reflecting a metabolic shift that promoted cellular oxidative stress and apoptosis.
69
Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.
Jia Qu,Jia Qu,Wenyi Sun,Jie Zhong,Hao Lv,Mingrui Zhu,Jun Xu,Nan Jin,Zuoquan Xie,Minjia Tan,Shuhai Lin,Meiyu Geng,Jian Ding,Jian Ding,Min Huang +14 more
TL;DR: It is reported that PGAM1 is required for homologous recombination (HR) repair of DNA double-strand breaks (DSBs) caused by DNA-damaging agents, and a potential therapeutic opportunity for PGAM 1 inhibitors in combination with PARP inhibitors is revealed.