Nan Hao
University of Adelaide
26 Papers
68 Citations
Nan Hao is an academic researcher from University of Adelaide. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 11, co-authored 18 publications. Previous affiliations of Nan Hao include Commonwealth Scientific and Industrial Research Organisation.
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Papers
The emerging roles of AhR in physiology and immunity.
Nan Hao,Murray L. Whitelaw +1 more
TL;DR: Gen knock out studies suggest that AhR is indispensable for the postnatal maintenance of intestinal intraepithelial lymphocytes and skin-resident dendritic epidermal gamma delta T cells, providing a potential link between AhR and gut immunity and wound healing.
213
Programmable DNA looping using engineered bivalent dCas9 complexes.
TL;DR: A Cas9-based dimerization system for inducing DNA loops in E. coli, allowing activation and rewiring of gene expression and enabling creation of new regulatory connections is designed.
The aryl hydrocarbon receptor links integrin signaling to the TGF-β pathway
Manuela Silginer,Isabel Burghardt,Dorothee Gramatzki,Lukas Bunse,Henning Leske,Elisabeth J. Rushing,Nan Hao,Michael Platten,Michael Weller,Patrick Roth +9 more
TL;DR: It is demonstrated that integrin inhibition, using αv, β3 or β5 neutralizing antibodies, RNA interference-mediated integrin gene silencing or pharmacological inhibition by the cyclic RGD peptide EMD 121974 (cilengitide) or the non-peptidic molecule GLPG0187, inhibits AhR activity.
55
Road rules for traffic on DNA—systematic analysis of transcriptional roadblocking in vivo
TL;DR: Protein binding kinetics can be tuned to maintain site occupation while reducing detrimental roadblocking, as reduced occupancy of the roadblock site by increasing the LacI off-rate increased dislodgement strongly, giving a stronger effect on readthrough than decreasing the lacI on-rate.
Reciprocal regulation of the basic helix–loop–helix/Per–Arnt–Sim partner proteins, Arnt and Arnt2, during neuronal differentiation
TL;DR: Regulation of the neuron-enriched Arnt paralogue, Arnt2, is investigated to allow specific functions of neuronal bHLH/PAS factors and/or to avoid neuronal b HLH/ PAS factors from interfering with AhR/Arnt signalling.