Nan Chen
5 Papers
Nan Chen is an academic researcher. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 1, co-authored 3 publications.
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Papers
Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation.
Anni Zhang,Y. Xia,Jeffrey S.H. Lin,Ken H. Chu,Wei Chuan K. Wang,Titine Ruiter,Jenny C. C. Yang,Nan Chen,Justin Chhuor,Shilpa Tukaram Patil,Haoning Cen,Elizabeth J. Rideout,Vincent Richard,David F. Schaeffer,R. Zahedi,Christoph H. Borchers,James D. Johnson,Janel L. Kopp +17 more
TL;DR: It is demonstrated that insulin receptors (Insr) in KrasG12D-expressing pancreatic acinar cells are dispensable for glucose homeostasis but necessary for hyperinsulinemia-driven PanIN formation in the context of diet-induced hyperinsULinemia and obesity.
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Title: Insulin receptors in pancreatic acinar cells contribute to Kras G12D -driven cancer initiation in the context of diet-induced obesity
Anni Zhang,Y. Xia,Ken H. Chu,Titine Ruiter,Jenny C. C. Yang,Jeffrey,Nan Chen,Justin Chhuor,Shilpa Tukaram Patil,Haoning Cen,Elizabeth J. Rideout,Vincent Richard,David F. Schaeffer,R. Zahedi,Christoph H. Borchers,David E. James,Johnson,Janel L. Kopp +17 more
TL;DR: context of diet-induced obesity Authors: Anni M.Y. Zhang, Yi Han Xia, Ken H.J. Yang, Jeffrey S.C. Ruiter, Jenny C. Rideout, Vincent R. Richard, David F. Schaeffer, Rene P. Zahedi.
Abstract B055: Hyperinsulinemia acts via acinar cell insulin receptors to drive obesity-associated pancreatic cancer initiation
Y. Xia,Jeffrey S.H. Lin,Ken H. Chu,Wei Chuan K. Wang,Titine Ruiter,Jenny C. C. Yang,Nan Chen,Justin Chhuor,Shilpa Tukaram Patil,Haoning Cen,Elizabeth J. Rideout,Vincent Richard,David F. Schaeffer,R. Zahedi,Christoph H. Borchers,James D. Johnson,Janel L. Kopp +16 more
TL;DR: Testing whether insulin receptor (Insr) in KrasG12D-expressing pancreatic acinar cells was necessary for the effects of diet-induced hyperinsulinemia on pancreatic cancer development demonstrated that insulin action on the insulin receptor in acinar cells promotes conditions that cooperate with Kras signaling to increase the risk of developing pancreatic cancer.
GABA treatment does not induce neogenesis of new endocrine cells from pancreatic ductal cells
TL;DR: In this paper , the effect of long-term administration of gamma-aminobutyric acid (GABA) on the pancreatic islet islet neogenesis was investigated.
Hyperinsulinemia acts via acinar insulin receptors to drive obesity-associated pancreatic cancer initiation by promoting digestive enzyme production and inflammation
Anni Zhang,Y. Xia,Jeffrey H. Lin,Ken H. Chu,Titine Ruiter,Jenny C. C. Yang,Nan Chen,Justin Chhuor,Shilpa Tukaram Patil,Haoning Cen,Elizabeth J. Rideout,Vincent Richard,David F. Schaeffer,R. Zahedi,Christoph H. Borchers,James D. Johnson,Janel L. Kopp +16 more
TL;DR: Testing whether insulin receptors (Insr) in KrasG12D-expressing pancreatic acinar cells are necessary for the effects of hyperinsulinemia on obesity-associated pancreatic cancer development demonstrates that hyperinsulainemia acting via acinar Cells insulin receptors promotes inflammatory conditions that cooperate with Kras signaling to increase the risk of developing pancreaticcancer, mechanistically linking obesity and pancreatic cancers.