24 Papers
Nam Che is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Candidate gene & Biology. The author has an hindex of 19, co-authored 22 publications.
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Papers
Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
Diana M. Shih,Zeneng Wang,Richard G. Lee,Yonghong Meng,Nam Che,Sarada Charugundla,Hannah Qi,Judy Wu,Calvin Pan,J. Mark Brown,Thomas Q. de Aguiar Vallim,Brian J. Bennett,Mark J. Graham,Stanley L. Hazen,Aldons J. Lusis +14 more
TL;DR: The results indicate a major role for FMO3 in modulating glucose and lipid homeostasis in vivo, and they suggest that pharmacologic inhibition of F MO3 to reduce TMAO levels would be confounded by metabolic interactions.
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The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue
Rebecca C. Schugar,Diana M. Shih,Manya Warrier,Robert N. Helsley,Amy C. Burrows,Daniel Ferguson,Amanda L. Brown,Anthony D. Gromovsky,Markus Heine,Arunachal Chatterjee,Lin Li,Xinmin S. Li,Zeneng Wang,Belinda Willard,Yong Hong Meng,Hanjun Kim,Nam Che,Calvin Pan,Richard G. Lee,Rosanne M. Crooke,Mark J. Graham,Richard E. Morton,Carl D. Langefeld,Swapan K Das,Lawrence L. Rudel,Nizar N. Zein,Arthur J. McCullough,Srinivasan Dasarathy,W.H. Wilson Tang,Bernadette O. Erokwu,Christopher A Flask,Markku Laakso,Mete Civelek,Sathyamangla V. Naga Prasad,Joerg Heeren,Aldons J. Lusis,Stanley L. Hazen,J. Mark Brown +37 more
TL;DR: It is demonstrated that the gut microbiota-initiated trimethylamine N-oxide (TMAO)-generating pathway is linked to obesity and energy metabolism and complimentary mouse and human studies indicate a negative regulatory role for FMO3 in the beiging of white adipose tissue.
251
NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection
Berenice Barajas,Nam Che,Fen Yin,Amir Rowshanrad,Luz D. Orozco,Ke Wei Gong,Xuping Wang,Lawrence W. Castellani,Karen Reue,Aldons J. Lusis,Jesus A. Araujo +10 more
TL;DR: Nrf2 expression unexpectedly promotes atherosclerotic lesion formation in a sex-dependent manner, most likely by a combination of systemic metabolic and local vascular effects.
167
Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages
Luz D. Orozco,Brian J. Bennett,Charles R. Farber,Anatole Ghazalpour,Calvin Pan,Nam Che,Ping-Zi Wen,Hong Xiu Qi,Adonisa Mutukulu,Nathan O. Siemers,Isaac M. Neuhaus,Roumyana Yordanova,Peter S. Gargalovic,Matteo Pellegrini,Todd G. Kirchgessner,Aldons J. Lusis +15 more
TL;DR: A systems genetics strategy is used to examine the role of common genetic variation in macrophage responses to inflammatory stimuli and identified the gene 2310061C15Rik as a regulator of inflammatory responses in Macrophages.
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Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics
Haijin Meng,Iset Medina Vera,Nam Che,Xuping Wang,Susanna S. Wang,Leslie Ingram-Drake,Eric E. Schadt,Thomas A. Drake,Aldons J. Lusis +8 more
TL;DR: It is demonstrated that in the cross, the expression of Abcc6 is highly correlated with the local mineralization regulatory system and the BMP2-Wnt signaling pathway known to be involved in the systemic regulation of calcification, suggesting potential pathways for the action of AbCC6 in DCC.
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