Nagayasu Egawa
University of Tokyo
13 Papers
232 Citations
Nagayasu Egawa is an academic researcher from University of Tokyo. The author has contributed to research in topics: Membrane protein & Gene. The author has an hindex of 9, co-authored 13 publications. Previous affiliations of Nagayasu Egawa include National Cancer Research Institute.
Chat about Author
Papers
Membrane Type 1 Matrix Metalloproteinase (MT1-MMP/MMP-14) Cleaves and Releases a 22-kDa Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Fragment from Tumor Cells
Nagayasu Egawa,Naohiko Koshikawa,Taizo Tomari,Kazuki Nabeshima,Toshiaki Isobe,Motoharu Seiki +5 more
TL;DR: The MT1-MMP-dependent cleavage eliminates the functional N-terminal domain of EMMPRIN from the cell surface, which is expected to down-regulate its function and may mediate the expression of MMPs in tumor tissues.
136
The E1 Protein of Human Papillomavirus Type 16 Is Dispensable for Maintenance Replication of the Viral Genome
Nagayasu Egawa,Tomomi Nakahara,Shin Ichi Ohno,Mako Narisawa-Saito,Takashi Yugawa,Masatoshi Fujita,Kenji Yamato,Yukikazu Natori,Tohru Kiyono +8 more
TL;DR: It is demonstrated that the E1 protein is dispensable for maintenance replication but not for initial and productive replication of HPV16.
84
Human papillomavirus-associated plantar epidermoid cyst related to epidermoid metaplasia of the eccrine duct epithelium: a combined histological, immunohistochemical, DNA-DNA in situ hybridization and three-dimensional reconstruction analysis.
TL;DR: It is proposed that certain palmoplantar epidermoid cysts may be related to eccrine ducts and that human papillomavirus (HPV) 60 may play a role in their pathomechanism.
41
High throughput analysis of proteins associating with a proinvasive MT1‐MMP in human malignant melanoma A375 cells
Taizo Tomari,Naohiko Koshikawa,Takayuki Uematsu,Takashi Shinkawa,Daisuke Hoshino,Nagayasu Egawa,Toshiaki Isobe,Motoharu Seiki +7 more
TL;DR: This study identifies 158 proteins including several previously reported to bind MT1‐MMP, although most had not previously been identified, and provides a valuable resource to identify substrates and regulators of MT1-MMP in tumor cells.
30
Enhanced specificity of HPV16 E6E7 siRNA by RNA-DNA chimera modification.
Kenji Yamato,Nagayasu Egawa,Shinji Endo,Kumiko Ui-Tei,Taketo Yamada,K. Saigo,Ichinosuke Hyodo,Tohru Kiyono,Ichiro Nakagawa +8 more
TL;DR: Results show that dsRDC modification enhances the specificity of E6E7 siRNA, which is required for use in in vivo settings, and reduces nonspecific cytotoxicity in two of three siRNAs.