Nadine Taubenheim
Walter and Eliza Hall Institute of Medical Research
11 Papers
158 Citations
Nadine Taubenheim is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: B cell & Plasma cell differentiation. The author has an hindex of 9, co-authored 9 publications. Previous affiliations of Nadine Taubenheim include French Institute of Health and Medical Research & Paris Descartes University.
Chat about Author
Papers
The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage
Grant S. Stewart,Stephanie Panier,Stephanie Panier,Kelly Townsend,Abdallah Al-Hakim,Nadine K. Kolas,Edward S. Miller,Shinichiro Nakada,Jarkko Ylanko,Jarkko Ylanko,Signe Olivarius,Megan Mendez,Ceri E. Oldreive,Jan Wildenhain,Andrea Tagliaferro,Laurence Pelletier,Laurence Pelletier,Nadine Taubenheim,Anne Durandy,Philip J. Byrd,Tatjana Stankovic,A. Malcolm R. Taylor,Daniel Durocher,Daniel Durocher +23 more
TL;DR: It is reported that the ubiquitin ligase RNF168 is mutated in the RIDDLE syndrome, a recently discovered immunodeficiency and radiosensitivity disorder and their loss is the likely cause of the cellular and developmental phenotypes associated with RIDdLE syndrome.
802
Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells
Wei Shi,Yang Liao,Simon N. Willis,Nadine Taubenheim,Michael Inouye,David M. Tarlinton,Gordon K. Smyth,Philip D. Hodgkin,Stephen L. Nutt,Lynn M. Corcoran +9 more
TL;DR: The transcriptomes of many mature B cell populations and stages of plasma cell differentiation in mice are defined and a molecular signature of ASCs is provided that highlights the stark transcriptional divide between B cells and plasma cells and enables the demarcation ofASCs on the basis of location and maturity.
358
Memory switched B cell percentage and not serum immunoglobulin concentration is associated with clinical complications in children and adults with specific antibody deficiency and common variable immunodeficiency.
TL;DR: In patients with idiopathic humoral immunodeficiencies assessment of B cell switching more accurately predicts clinical prognosis than either classification of patients into SAD and CVID or serum immunoglobulin concentrations.
118
Defined blocks in terminal plasma cell differentiation of common variable immunodeficiency patients.
Nadine Taubenheim,Marcus von Hornung,Anne Durandy,Klaus Warnatz,Lynn M. Corcoran,Hans-Hartmut Peter,Hermann Eibel +6 more
TL;DR: B cells reaching only the first stage of plasma cell differentiation were further unable to undergo isotype switching and to up-regulate activation markers on B cells stimulated in vitro.
75
A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair
Sophie Péron,Qiang Pan-Hammarström,Kohsuke Imai,Likun Du,Nadine Taubenheim,Nadine Taubenheim,Ozden Sanal,László Maródi,Anne Bergelin-Besançon,Malika Benkerrou,Jean-Pierre de Villartay,Jean-Pierre de Villartay,Jean-Pierre de Villartay,Alain Fischer,Alain Fischer,Alain Fischer,Patrick Revy,Patrick Revy,Anne Durandy,Anne Durandy,Anne Durandy +20 more
TL;DR: Analysis of the cells of five affected patients showed that the Ig CSR deficiency was associated with an abnormal formation of the S junctions characterized by microhomology and with increased cell radiosensitivity, suggesting that a unique IgCSR deficiency phenotype could be related to an as-yet-uncharacterized defect in a DNA repair pathway involved in both CSR and SHM events.
46