Nadine Gillich
University of Freiburg
5 Papers
Nadine Gillich is an academic researcher from University of Freiburg. The author has contributed to research in topics: Biology & MDA5. The author has an hindex of 1, co-authored 1 publications.
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Papers
Modularized CRISPR/dCas9 effector toolkit for target-specific gene regulation.
Michael Agne,Ilona Blank,Alica J. Emhardt,Christoph G Gäbelein,Fenja Gawlas,Nadine Gillich,Patrick Gonschorek,Thomas J Juretschke,Stefan D Krämer,Natalie Louis,Anne Müller,Alina Rudorf,Lisa M Schäfer,Manuel C. Scheidmann,Lisa J Schmunk,Philipp Schwenk,Maximilian R Stammnitz,Philipp M Warmer,Wilfried Weber,Adrian Fischer,Beate Kaufmann,Hanna J. Wagner,Gerald Radziwill +22 more
TL;DR: A standardized toolkit utilizing an engineered CRISPR/Cas9 system that enables customizable gene regulation in mammalian cells is developed, which comprises a modular RNAimer plasmid, which encodes the required noncoding RNA components.
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Effect of variants in LGP2 on MDA5-mediated activation of interferon response and suppression of hepatitis D virus replication.
TL;DR: In this paper , the role of LGP2 and clinically relevant variants thereof in these processes was revealed, and the authors demonstrated that the immune sensor cooperates with MDA5 to mount an antiviral interferon (IFN) response that represses HDV replication.
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Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation
Ombretta Colasanti,Rani Burm,Hao En Huang,Tobias Riedl,Jannik Traut,Nadine Gillich,Teng-Feng Li,Laura Corneillie,Suzanne Faure-Dupuy,Oliver Grünvogel,Danijela Heide,Ji-Young Lee,Cong Si Tran,Uta Merle,Maria Chironna,Florian W. R. Vondran,Katharina Esser-Nobis,Marco Binder,Ralf Bartenschlager,Mathias F. Heikenwälder,Philip Meuleman,Volker Lohmann +21 more
TL;DR: In this article, the authors investigated the mechanisms of HAV and hepatitis C virus (HCV) induction and counteraction by HAV proteases in vivo and in vitro and found that HAV 3ABC and 3CD proteases do not abolish the host innate immune response.
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Reconstitution of interferon regulatory factor 7 expression restores interferon beta induction in Huh7 cells
Andreas Betz,Zuguang Gu,Ombretta Colasanti,Teng-Feng Li,Jasper Hesebeck-Brinckmann,Nadine Gillich,Gnimah Eva Gnouamozi,Matthias Schlesner,Florian W R Vondran,Stephan Urban,Ralf Bartenschlager,Marco Binder,Volker Lohmann +12 more
Corrigendum to "Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation" [J Hepatol (2023) 645-656].
Ombretta Colasanti,Rani Burm,Hao-En Huang,Tobias Riedl,Jannik Traut,Nadine Gillich,Teng-Feng Li,Laura Corneillie,Suzanne Faure-Dupuy,Oliver Grünvogel,Danijela Heide,Ji-Young Lee,Cong Si Tran,Uta Merle,Maria Chironna,Florian F W Vondran,Katharina Esser-Nobis,Marco Binder,Ralf Bartenschlager,Mathias Heikenwälder,Philip Meuleman,Volker Lohmann +21 more
TL;DR: A corrigendum corrects an error in Fig. 4G of a study comparing HAV and HCV infections, where HAV's 3ABC protein size was mislabelled as 75 kDa instead of 38 kDa, affecting understanding of immune evasion mechanisms.