9 Papers
Na Li is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 4, co-authored 6 publications. Previous affiliations of Na Li include University of Medicine and Health Sciences.
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Papers
ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment.
Na Li,Yuqi Kang,Lingling Wang,Sarah Huff,Rachel Tang,Hui Hui,Kriti Agrawal,Gwendolyn Gonzalez,Yinsheng Wang,Sandip Pravin Patel,Tariq M. Rana +10 more
TL;DR: It is shown that deletion of the m6A demethylase Alkbh5 sensitized tumors to cancer immunotherapy and identified ALKBH5 as a potential therapeutic target to enhance immunotherapy outcome in melanoma, colorectal, and potentially other cancers.
m 6 A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
TL;DR: These findings uncover a new awareness of the function of RNA methylation in adaptive immunity and provide METTL3 and METTL14 as potential therapeutic targets in anticancer immunotherapy.
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METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.
Na Li,Hui Hui,Bill Bray,Gwendolyn Gonzalez,Mark Zeller,Kristian G. Anderson,Rob Knight,Davey M. Smith,Yinsheng Wang,Aaron F. Carlin,Tariq M. Rana +10 more
TL;DR: In this paper, the authors investigated m6A modification of the SARS-CoV-2 gene in regulating the host cell innate immune response and found that depletion of the host-cell m6a methyltransferase METTL3 decreases m6As levels in SARS and host genes, and reduction in viral RNA increases RIGI binding and subsequently enhances the downstream innate immune signaling pathway and inflammatory gene expression.
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Immunopathobiology and therapeutic targets related to cytokines in liver diseases
Yong He,Seonghwan Hwang,Yeni Ait Ahmed,Yeni Ait Ahmed,Dechun Feng,Na Li,Marcelle de Carvalho Ribeiro,Fouad Lafdil,Tatiana Kisseleva,Gyongyi Szabo,Bin Gao +10 more
TL;DR: This review discusses recent data on a large number of cytokines that play important roles in regulating liver injury, inflammation, fibrosis, and regeneration, with a focus on interferons and T helper (Th) 1, Th2, Th9, Th17, interleukin (IL)-1 family, IL-6 family, and IL-20 family cytokines.
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Regulation of antiviral innate immunity by chemical modification of viral RNA
Na Li,Tariq M. Rana +1 more
TL;DR: The current understanding of the mechanisms by which the RNA modifications such as N6 -methyladenosine (m6A), N6 ,2'-O-dimethyladenosines (n6Am), 5-methylcytidine (m5C), N4-acetylcytazine (ac4C), and 2'-O'methylation (Nm) promote viral replication and/or suppress recognition by innate sensors and downstream activation of the host antiviral response is discussed
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