N. Stransky
6 Papers
N. Stransky is an academic researcher. The author has contributed to research in topics: Immunology & Inflammatory bowel disease. The author has co-authored 4 publications.
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Papers
Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth
Ali Rashidfarrokhi,Ray Pillai,Yuan Zhang Hao,Warren L. Wu,Sofia Dimitriadoy,Anna H. Yeaton,Shih-Ming Huang,Arjun Bhutkar,Alberto Herrera,Sahith Rajalingam,Makiko Hayashi,Kuan-Lin Huang,Anastasia Maria Zavitsanou,Corrin A. Wohlhieter,Sarah E. LeBoeuf,Ting Chen,Cynthia A. Loomis,Valeria Mezzano,Ruth Kulicke,Fred P. Davis,N. Stransky,Gromoslaw A. Smolen,Charles M. Rudin,Andre L. Moreira,Kamal M. Khanna,Harvey I. Pass,Kwok-Kin Wong,Shohei Koide,Aristotelis Tsirigos,Sergei B. Koralov,Thales Papagiannakopoulos +30 more
TL;DR: In this paper , the authors used genetically engineered lung cancer mouse models and patient samples to dissect how LKB1 mutations accelerate tumor growth by reshaping the immune microenvironment, and they discovered a novel mechanism whereby autocrine LIF signaling in Lkb1-mutant tumors drives tumorigenesis by reprogramming myeloid cells in the immun microenvironment.
DOP02 Single cell RNA sequencing of Ulcerative Colitis and Crohn's Disease tissue samples informs the selection of Triggering Receptors Expressed on Myeloid Cells 1 (TREM1) as a target for the treatment of Inflammatory Bowel Diseases
S. Grant,Kalyn Johnson,Thomas D.C. Thomas,G. Honig,Pawel Bielecki,Calliope A. Dendrou,S. Guo,Ruth Kulicke,L. L'Italien,N. Spies,N. Stransky,Holm H. Uhlig,Motapalkula Sreenivas Varma,Simon Travis,C Buckley,Jeanne Magram +15 more
TL;DR: In this article , the authors performed single cell RNA sequencing on tissue samples collected from Crohn's disease patients before and after beginning adalimumab and found that inflammatory monocytes were highly enriched in inflammatory bowel disease (IBD) inflamed samples.
Abstract 738: Single-cell trajectories of metastatic urothelial cancer and individual patterns of resistance to immune checkpoint inhibitors
Ronan Flippot,Amélie Roehrig,Julien Vibert,N. Stransky,Luc Cabel,Kevin Mulder,B. Besse,Claudio Nicotra,M. Ngo Camus,Christophe Massard,E. Rouleau,Gerome Jules-Clément,Alicia Tran-Dien,L. Tselikas,Fabrice André,Jean-Yves Scoazec,Céline Vallot,Maud Kamal,Eric Letouze,Yohann Loriot +19 more
Abstract B017: Single-cell proteogenomic profiling reveals immune cell networks in renal cell carcinoma
Keith A Lawson,Shirley Hui,Daniel Stueckmann,Xiaoyu Zhang,Jalna Meens,Lisa Martin,Maria Komisarenko,Julia Szusz,Stephane Chevrier,Sujana Sivapatham,Philip Jonsson,Fred Davis,Cristina Penaranda,Ryan Newton,N. Stransky,Piotr Bielecki,Zhihui Liu,Jennifer Pfeil,Sarah Crome,Dominik Deniffel,Masoom A Haider,Jason Lee,Neil E Fleshner,Nathan Perlis,Robert Hamilton,Girish S. Kulkarni,Susan Prendeville,Hartland Jackson,Laurie Ailles,Gromoslaw A. Smolen,Bernd Bodenmiller,Gary Bader,Antonio Finelli +32 more
TL;DR: This study provides the largest single-cell proteogenomic characterization of RCC to date, detailing co-occurring immune cell phenotypes across heterogenous patient tumor microenvironments and leveraged this data to characterize a pro-inflammatory immune cell ecotype of R CC with potential prognostic and predictive implications that warrant further validation.
Single cell rna sequencing of ulcerative colitis and crohn's disease tissue samples informs the selection of trem1 as a target for the treatment of inflammatory bowel diseases
Sarah Grant,Kristen Johnson,Tom Thomas,Gerard Honig,Piotr Bielecki,Calliope A. Dendrou,S. Guo,Ruth Kulicke,Ping Li,L. L'Italien,Noah Spies,N. Stransky,Holm H. Uhlig,Mukund Varma,Simon Travis,Christopher D. Buckley,Jeanne Magram +16 more
TL;DR: In this article , single cell RNA sequencing data were used to identify potential mediators of persistent inflammation in inflammatory bowel disease (IBD), and a highly potent and selective monoclonal antibody inhibitor of TREM-1 was developed.