N. Manamela
20 Papers
2 Citations
N. Manamela is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 6, co-authored 12 publications.
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Papers
Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern
Dale Kitchin,Simone I. Richardson,M. A. Van Der Mescht,T. Motlou,Nonkululeko Betty Mzindle,Thandeka Moyo-Gwete,Z. Makhado,F. Ayres,N. Manamela,Holly A. Spencer,Bronwen E. Lambson,Brent Oosthuysen,Haajira Kaldine,Marizane du Pisanie,M. Mennen,S. Skelem,Noleen Williams,Ntobeko A.B. Ntusi,Wendy A. Burgers,G. Gray,Linda-Gail Bekker,Michael T. Boswell,Theresa M. Rossouw,Veronica Ueckermann,Penny L. Moore +24 more
TL;DR: Wibmer et al. as discussed by the authors showed that neutralizing and binding antibody responses to Ad26.COV2.S vaccination are stable for 6 months post-vaccination, when tested against multiple SARS-CoV-2 variants.
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Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage
Cathrine Scheepers,J.S. Everatt,Daniel G. Amoako,Houriiyah Tegally,Constantinos Kurt Wibmer,A. Mnguni,Arshad Ismail,B. Pinky Mahlangu,Bronwen E. Lambson,Darren P. Martin,Eduan Wilkinson,James Emmanuel San,Jennifer Giandhari,N. Manamela,Noxolo N. Ntuli,Prudence Kgagudi,Sandile Cele,Simone I. Richardson,Sureshnee Pillay,Thabo Mohale,U. Ramphal,Yeshnee Naidoo,Zamantungwa T. H. Khumalo,Gaurav Kwatra,G. Gray,Linda-Gail Bekker,Shabir A. Madhi,Vicky L. Baillie,Wesley C. Van Voorhis,Florette K. Treurnicht,Marietjie Venter,Koleka Mlisana,Nicole Wolter,Alex Sigal,Carolyn Williamson,Nei-yuan Hsiao,Nokukhanya Msomi,Tongai Maponga,Wolfgang Preiser,Zinhle Makatini,Richard J Lessells,Penny L. Moore,Tulio de Oliveira,Anne von Gottberg,Jinal N. Bhiman +44 more
TL;DR: The PANGO lineage C.1.2 was detected at low prevalence in South Africa and eleven other countries as mentioned in this paper , and was associated with a high substitution rate, and includes changes within the spike protein that have been associated with increased transmissibility or reduced neutralization sensitivity in SARS-CoV-2 variants of concern or variants of interest.
Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005): a post-hoc analysis of a randomised, phase 1b–2a trial
Shabir A. Madhi,Gaurav Kwatra,Simone I. Richardson,Anthonet Koen,Vicky L. Baillie,Clare L. Cutland,Lee Fairlie,S D Padayachee,Keertan Dheda,Shaun Barnabas,Q E Bhorat,Carmen Briner,K. Ahmed,Parvinder K. Aley,Sutika Bhikha,As’ad E. Bhorat,Aliasgar Esmail,E Horne,Haajira Kaldine,Christian Kabasele Mukendi,V. S. Madzorera,N. Manamela,Mduduzi Masilela,Stephanus Hermanus,T. Motlou,Nonkululeko Betty Mzindle,Suzette Oelofse,Faeezah Patel,S Rhead,L. Rossouw,C Taoushanis,Samuel van Eck,Teresa Lambe,Sarah C. Gilbert,Andrew J. Pollard,Penny L. Moore,Alane Izu +36 more
- 01 Oct 2022
TL;DR: A single dose of AZD1222 in the general African population, where COVID-19 vaccine coverage is low and Sars-CoV-2 seropositivity is 90%, could enhance the magnitude and quality of antibody responses to SARS-Cov-2.
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Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera regardless of infecting variant
Simone I. Richardson,Prudence Kgagudi,N. Manamela,Haajira Kaldine,Elizabeth M. Venter,Thanusha Devi Pillay,Bronwen E. Lambson,M. A. Van Der Mescht,Tandile Hermanus,Sashkia R Balla,Zelda de Beer,Talita Roma de Villiers,A. Bodenstein,Gretha van den Berg,Marizane du Pisanie,Wendy A. Burgers,Ntobeko A.B. Ntusi,Fareed Abdullah,Veronica Ueckermann,Theresa M. Rossouw,Michael T. Boswell,Penny L. Moore +21 more
TL;DR: In this article , the authors assess the sensitivity of BA.4 to binding, neutralization, and antibody-dependent cellular cytotoxicity (ADCC) potential, measured by FcγRIIIa signaling, in convalescent donors infected with four previous variants of SARS-CoV-2, as well as in post-vaccination breakthrough infections (BTIs) caused by Delta or BA.1.
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Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants
Thandeka Moyo-Gwete,Mashudu Madzivhandila,Nonhlanhla N. Mkhize,Prudence Kgagudi,F. Ayres,Bronwen E. Lambson,N. Manamela,Simone I. Richardson,Z. Makhado,M. A. Van Der Mescht,Zelda de Beer,T. R. de Villiers,Wendy A. Burgers,Ntobeko A.B. Ntusi,Theresa M. Rossouw,Veronica Ueckermann,Michael T. Boswell,Penny L. Moore +17 more
TL;DR: Understanding antibody responses elicited by different SARS-CoV-2 variants and to define shared epitopes is sought, showing that Beta and Delta infections resulted in antibody responses that were more cross-reactive than the original D614G variant, but they had differing patterns ofCross-reactivity.
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