11 Papers
259 Citations
N. Ledirac is an academic researcher from Institut national de la recherche agronomique. The author has contributed to research in topics: HaCaT & Northern blot. The author has an hindex of 10, co-authored 11 publications.
Chat about Author
Papers
Inferential, robust non-negative matrix factorization analysis of microarray data
TL;DR: A non-negative matrix factorization methods that create ordered sets of predictors and statistical testing within ordered sets which is done sequentially, removing the need for correction for multiple testing within the set.
Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells
C. Delescluse,N. Ledirac,Rouya Li,Marie P. Piechocki,Ronald N. Hines,Xavier Gidrol,Roger Rahmani +6 more
TL;DR: Observations support the notion that intracellular signals leading to CYP1A1 induction, oxidative stress, and genotoxicity are intimately related, as demonstrated by the dose-dependent increase in reporter CAT and CYP 1A1 mRNAs.
92
Effects of Organochlorine Insecticides on MAP Kinase Pathways in Human HaCaT Keratinocytes: Key Role of Reactive Oxygen Species
TL;DR: This study indicates that OCs strongly activate the ERK1/2 pathway, and it identifies a critical role of ROS in OC-induced ERK activation, probably by stabilizing its phosphorylation.
71
Cytotoxic effects and induction of cytochromes P450 1A1/2 by insecticides, in hepatic or epidermal cells: binding capability to the Ah receptor
TL;DR: Except for cypermethrin and diflubenzuron, all these chemicals exerted a cytotoxic effect in hepatocytes and HaCaT, but not in HepG2 cells, suggesting that they would not be a ligand of the Ah receptor.
48
Endosulfan decreases cell growth and apoptosis in human HaCaT keratinocytes: partial ROS-dependent ERK1/2 mechanism.
Sébastien Anthérieu,N. Ledirac,Anne-Pascale Luzy,Philippe Lenormand,Jean-Claude Caron,Roger Rahmani +5 more
TL;DR: Findings strongly support that endosulfan induces ROS generation leading to sustained ERK1/2 phosphorylation and decrease in cell growth, and this could contribute to mutant cell survival and therefore have possible carcinogenic effects.
42