N. Figg
University of Cambridge
7 Papers
11 Citations
N. Figg is an academic researcher from University of Cambridge. The author has contributed to research in topics: Senescence & Vascular smooth muscle. The author has an hindex of 3, co-authored 7 publications.
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Papers
Vascular Smooth Muscle Cells Undergo Telomere-Based Senescence in Human Atherosclerosis. Effects of Telomerase and Oxidative Stress
Charles Matthews,Isabelle Gorenne,Stephen Scott,N. Figg,Peter J. Kirkpatrick,Andrew J. Ritchie,Martin Goddard,Martin R. Bennett +7 more
TL;DR: It is concluded that human atherosclerosis is characterized by senescence of VSMCs, accelerated by oxidative stress-induced DNA damage, inhibition of telomerase and marked telomere shortening.
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Statins Use a Novel Nijmegen Breakage Syndrome-1–Dependent Pathway to Accelerate DNA Repair in Vascular Smooth Muscle Cells
TL;DR: It is concluded that statin treatment activate a novel mechanism of accelerating DNA repair, dependent on NBS-1 stabilization and Hdm2, which may delay cell senescence and promote DNA repair in atherosclerosis.
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Differential cyclin E expression in human in-stent stenosis smooth muscle cells identifies targets for selective anti-restenosis therapy
Michael O'Sullivan,Stephen Scott,Nicola McCarthy,N. Figg,Leonard M. Shapiro,Peter J. Kirkpatrick,Martin R. Bennett +6 more
TL;DR: Human ISS- VSMCs have marked differences in the stable expression of multiple cell cycle regulators, suggesting that ISS-VSMCs derive from P-VS MCs driven to proliferate through cyclin E overexpression, and the critical role forcyclin E-CDK2 enables the identification of the first agent that selectively inhibits ISS-vsMC proliferation.
Glucagon-Like Peptide-1-Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion.
Joel P. Giblett,Richard G. Axell,Paul A. White,Muhammad Aetesam-Ur-Rahman,Sophie J. Clarke,N. Figg,Martin R. Bennett,Nick E.J. West,Stephen P. Hoole +8 more
TL;DR: In this article, the authors assessed whether serial right coronary artery balloon occlusion affected the right ventricle in a similar fashion using a conductance catheter method, and they found that balloon occlation of the right artery causes stunning and cumulative ischemic dysfunction.
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