Various chlorinated technical compounds, namely, 2,4,5-trichlorophenol, 2,4,5-trichlorophen-oxyacetic acid (2,4,5-T), and European chlorinated biphenyls (Phenoclor DP6 and Clophen A60), have been found to be contaminated with trace amounts of chlorinated dibenzofurans or chlorinated dibenzodioxins. Toxic fat which produces hydropericardium in chickens also contains chlorinated dibenzodioxins. These and other technical chlorinated compounds such as the technical pentachlorophenol have been implicated in causing chloracne, liver disease, teratogenicity, x-disease in cattle, and chick edema. The literature on the toxicity of the chlorinated technical compounds is reviewed. It is mentioned that 2,4,5-T and the chlorinated biphenyls also induce porphyria. Whether the various disease entities are caused by the contaminants, combinations of the chemical and its contaminants or by the chemicals themselves needs further evaluation.

Toxicity of chlorinated hydrocarbons and related compounds. A review including chlorinated dibenzodioxins and chlorinated dibenzofurans.

Persistent pollutants: A brief history of the discovery of the widespread toxicity of chlorinated hydrocarbons

http://www.aipro.info/drive/File/Pollutant%20concentrations%20in%20placenta.%20O.%20Leino%20et%20al.,%2014%2004%2014.pdf

Pollutant concentrations in placenta.

Rats fed diets containing 0.1 percent of three polychlorinated biphenyls (PCBs) (Arochlor 1248, Arochlor 1254, Arochlor 1262) for six weeks show a progressive enlargement of the liver. This liver hypertrophy is attributed to proliferation of the smooth endoplasmic reticulum, development of large membranous concentric arrays, and increase in lipid droplets within the cytoplasm of the affected liver cells. Liver homogenates show increased levels of protein and RNA and reduced concentrations of DNA. Microsomal fractions have increased levels of protein and phospholipids, and reduced levels of cholesterol. Also, there are modifications in the activity of certain hepatic microsomal enzymes. By the sixth week, the animals have progressed from a stimulatory effect on the liver by the PCBs to a stage where regressive hepatic changes are occurring, such as a decreased activity of microsomal enzymes, dissolution of concentric membrane arrays, vesiculation of the endoplasmic reticulum, and accumulation of lipid droplets within the cytoplasm of the affected cells.

Morphological and biochemical changes in the liver of rats fed polychlorinated biphenyls.

The toxicological profile of polychlorinated naphthalenes (PCNs).

Three cases of yellow atrophy of the liver have occurred in each of 3 widely separated plants and under different management within a year or two. In each instance where the illness appeared, the men were exposed to a chlorinated naphthalene heated above the melting point and giving off fumes. Yellow atrophy of the liver is a rare disease and there have been no cases reported where chlorinated naphthalene was the proven etiological agent.The following experiments were conducted to determine if some of the chlorinated naphthalenes might produce such lesions. Three naphthalenes obtained from one of the above factories were used in this work. They are designated then as A, B, and C.Compound A is a mixture of tri- and tetra-chlor-naphthalene. Compound B is a mixture of tetra- and penta-chlor-naphthalene and may contain some tri-chlor-naphthalene. Compound C is a mixture of penta- and hexa-chlor-naphthalene which is plasticized with a relatively small percentage of asphalt.Groups of 5 rabbits weighing approxim...

Action of Certain Chlorinated Naphthalenes on the Liver

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Action of Certain Chlorinated Naphthalenes on the Liver