Mutsuo Oyake
Niigata University
33 Papers
162 Citations
Mutsuo Oyake is an academic researcher from Niigata University. The author has contributed to research in topics: Dentatorubral-pallidoluysian atrophy & Biology. The author has an hindex of 19, co-authored 25 publications.
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Papers
Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein
Yasuteru Sano,Hidetoshi Date,Shuichi Igarashi,Osamu Onodera,Mutsuo Oyake,Toshiaki Takahashi,Shintaro Hayashi,Mitsunori Morimatsu,Hitoshi Takahashi,Takao Makifuchi,Nobuyoshi Fukuhara,Shoji Tsuji,Shoji Tsuji +12 more
TL;DR: The results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single‐strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.
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•Journal Article
Non-Mendelian transmission in dentatorubral-pallidoluysian atrophy and Machado-Joseph disease: the mutant allele is preferentially transmitted in male meiosis
Takeshi Ikeuchi,Shuichi Igarashi,Yoshihisa Takiyama,Osamu Onodera,Mutsuo Oyake,Hiroki Takano,Reiji Koide,Hirosato Tanaka,Shoji Tsuji +8 more
TL;DR: Analysis of segregation patterns in transmissions of autosomal dominant dentatorubral-pallidoluysian atrophy and Machado-Joseph disease pedigrees raised the possibility that a common molecular mechanism underlies the meiotic drive and the meiosis instability in male meiosis.
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Single Sperm Analysis of the CAG Repeats in the Gene for Machado-Joseph Disease (MJD1): Evidence for Non-Mendelian Transmission of the MJD1 Gene and for the Effect of the Intragenic CGG/GGG Polymorphism on the Intergenerational Instability
Yoshihisa Takiyama,Kumi Sakoe,Michiyo Soutome,M. Namekawa,T. Ogawa,Imaharu Nakano,Shuichi Igarashi,Mutsuo Oyake,Hirosato Tanaka,Shoji Tsuji,Masatoyo Nishizawa +10 more
TL;DR: Findings in single sperm confirm non-Mendelian transmission of the MJD1 gene and the effect of the intragenic CGG/GGG polymorphism on the intergenerational instability of the CAG repeats in the MJd1 gene, which have been observed in clinical and genetic studies.
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Neuropathology of sporadic amyotrophic lateral sclerosis of long duration
Keisuke Iwanaga,Keisuke Iwanaga,Shintaro Hayashi,Mutsuo Oyake,Yoh Horikawa,Tsunemi Hayashi,Masatoshi Wakabayashi,Hiroshi Kondo,Shoji Tsuji,Hitoshi Takahashi +9 more
TL;DR: It is thought that these three patients with progressive neurogenic amyotrophy of long duration, with long disease durations, were affected by essentially the same underlying disease process as that of sporadic, classical ALS.
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Long-term therapeutic efficacy and safety of low-dose tacrolimus (FK506) for myasthenia gravis.
Masayoshi Tada,Takayoshi Shimohata,Mari Tada,Mutsuo Oyake,Shuichi Igarashi,Osamu Onodera,Satoshi Naruse,Keiko Tanaka,Shoji Tsuji,Masatoyo Nishizawa +9 more
TL;DR: This study indicates that low-dose FK506 treatment may be efficacious not only in controlling intractable myasthenic symptoms, but also in reducing steroid dosage, and that Fk506 is safe as an adjunctive drug to PSL for MG treatment for a maximum of 3 years.
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