Muthiah Manoharan

TL;DR: In this article, the authors present compositions and methods for the delivery of therapeutic agents to cells, such as novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic aicd to cells in vivo.

TL;DR: In this paper, the authors present compositions and methods for the delivery of therapeutic agents to cells, such as novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic aicd to cells in vivo.

TL;DR: In this paper, the authors provided iRNA agent including at least one monomer having the structure shown in formula (I') wherein: A and B are each independently for each occurrence O, N(R ) or S; X is H, a protecting group, a phosphate group, an activated phosphite group, and a phosphoramidite, a solid support, - P(Z')(Z")O-nucleoside, -P(Z')O-oligonucleotide, a lipid, a PEG, a steroid, a polymer,

TL;DR: Oligomer compositions comprising first and second oligomers are provided in this paper where at least a portion of the second oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first oligomers has a modified base for binding to a cytosine, uracil, or thymine base in the opposite strand.