Muriel Meier
French Institute of Health and Medical Research
8 Papers
97 Citations
Muriel Meier is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: BSCL2 & Congenital generalized lipodystrophy. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Muriel Meier include Pierre-and-Marie-Curie University.
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Papers
Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13.
Jocelyne Magré,Marc Delepine,Eliane Khallouf,Tobias Gedde-Dahl,Lionel Van Maldergem,Eric M. Sobel,Jeanette C. Papp,Muriel Meier,André Mégarbané,A. Bachy,Alain Verloes,F. H. D'abronzo,E. Seemanova,Roger Assan,N. Baudic,Bourut C,Paul Czernichow,Frédéric Huet,Florin Grigorescu,M. De Kerdanet,Didier Lacombe,Philippe Labrune,M. Lanza,H. Loret,Fumihiko Matsuda,J. Navarro,A. Nivelon-Chevalier,Meraida Polak,J.-J. Robert,P. Tric,N. Tubiana-Rufi,Corinne Vigouroux,Jean Weissenbach,S. Savasta,J. A. Maassen,O. Trygstad,P. Bogalho,P. Freitas,J. L. Medina,F. Bonnicci,Barry I Joffe,G. Loyson,Vanessa R. Panz,Frederick J. Raal,Stephen O'Rahilly,T. Stephenson,C R Kahn,Mark Lathrop,Jacqueline Capeau +48 more
TL;DR: A genome screen of nine BSCL families from two geographical clusters revealed mutations in a gene homologous to the murine guanine nucleotide-binding protein, γ3-linked gene (Gng3lg) in all BSCL2-linked families, of general importance for understanding the molecular mechanisms underlying regulation of body fat distribution and insulin resistance.
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Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy.
Chong Ae Kim,Marc Delepine,Emilie Boutet,Haquima El Mourabit,Soazig Le Lay,Muriel Meier,Mona Nemani,Etienne Bridel,Claudia da Costa Leite,Débora Romeo Bertola,Robert K. Semple,Stephen O'Rahilly,Isabelle Dugail,Jacqueline Capeau,Mark Lathrop,Jocelyne Magré +15 more
TL;DR: Findings identify CAV1 as a new BSCL-related gene and support a critical role for caveolins in human adipocyte function, which is a key structural component of plasma membrane caveolae, and Cav1-deficient mice display progressive loss of adipose tissue and insulin resistance.
Human peroxisome proliferator-activated receptor-gamma2: genetic mapping, identification of a variant in the coding sequence, and exclusion as the gene responsible for lipoatrophic diabetes.
Corinne Vigouroux,Lluis Fajas,Eliane Khallouf,Muriel Meier,G Gyapay,Olivier Lascols,Johan Auwerx,Jean Weissenbach,Jacqueline Capeau,Jocelyne Magré +9 more
TL;DR: A large number of patients with type 2 diabetes are at high-risk for developing central giant cell granuloma, and this research highlights the need to understand more fully the mechanisms leading to this condition.
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Leptin therapy for partial lipodystrophy linked to a PPAR‐γ mutation
Jean-Marc Guettier,Jean Y. Park,Elaine Cochran,Christine Poitou,Arnaud Basdevant,Muriel Meier,Muriel Meier,Karine Clément,Jocelyne Magré,Jocelyne Magré,Phillip Gorden +10 more
TL;DR: This is the first report to detail the clinical response of a patient with PL due to a PPARG mutation treated with r‐metHuLeptin.
Dominant Transmission of Insulin Resistance in a Type A Family Resulting From a Heterozygous Nonsense Mutation in the Insulin Receptor Gene and Associated With Decreased mRNA Level and Insulin Binding Sites
Jocelyne Magré,Christina Karayanni,Charalambos G Hadjiathanasiou,Christèle Desbois-Mouthon,Muriel Meier,Corinne Vigouroux,C. Stavrinadis,Constantinos Sinaniotis,Martine Caron,Jacqueline Capeau +9 more
TL;DR: The insulin receptor gene was studied in two first cousins with typical Type A syndrome and in seven of their relatives who had no history of consanguinity and revealed a heterozygous G-to-A substitution at the first base of intron 14, which belongs to a strictly conserved dinucleotide consensus sequence for RNA splicing (donor splice site).
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