Muneharu Doi
Takeda Pharmaceutical Company
34 Papers
224 Citations
Muneharu Doi is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Bacillus subtilis & Uridine. The author has an hindex of 9, co-authored 34 publications.
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Papers
Cloning of the Bacillus Subtilis IMP Dehydrogenase Gene and its Application to Increased Production of Guanosine
Kenichiro Miyagawa,Hiroyuki Kimura,Kazuo Nakahama,Masakazu Kikuchi,Muneharu Doi,Shun-ichi Akiyama,Yoshio Nakao +6 more
TL;DR: The introduction of the recombinant plasmid encoding IMP dehydrogenase to B. subtilis NA6128, an inosine overproducer, elevated its level of IMP dehydrogensase activity and remarkably increased the productivity of guanosine, accompanied by a decreased accumulation of inOSine.
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Microbial Production of L-Glutamic Acid by Glycerol Auxotrophs Part I
TL;DR: To establish a novel process for the production of L-glutamic acid from n-paraffins, a glycerol auxotroph GL-21, a new type mutant, was successfully obtained from Corynebacterium alkanolyticum No. 314 by treatment with N-methyl-N'-nitro-N-nitrosoguanidine.
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Patent
DNA and its use
Kenichiro Miyagawa,Kazuo Nakahama,Masakazu Kikuchi,Muneharu Doi +3 more
- 28 Nov 1984
TL;DR: In this paper, a DNA having a 5'-inosinate dehydrogenase gene and further having a Hind III cleavage site 2.9 kilo base pairs apart therefrom can be produced from the chromosomal DNA of a quanosine and/or xanthosine-producing strain of the genus Bacillus.
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Effects of Homoserine Dehydrogenase Deficiency on Production of Cytidine by Mutants of Bacillus subtilis.
TL;DR: A homoserine-requiring mutant, Bacillus subtilis strain No. 615, was isolated from a cytidine-producing mutant strain Nos. 515 and 615 and the effects of glucose concentration on cytidine production were examined.
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Regulation of Pyrimidine Nucleotide Biosynthesis in Cytidine Deaminase-negative Mutants of Bacillus subtilis
TL;DR: The role of uridine and cytidine compounds in regulating pyrimidine nucleotide biosynthesis de novo was studied with cytidine deaminase-negative mutants of Bacillus subtilis, and studies on feedback inhibition showed that the activity of CTP synthetase was inhibited by cytidine nucleotides, but not by uridineucleotides.
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