Motoyuki Sugai
Hiroshima University
198 Papers
1.7K Citations
Motoyuki Sugai is an academic researcher from Hiroshima University. The author has contributed to research in topics: Staphylococcus aureus & Biology. The author has an hindex of 55, co-authored 170 publications. Previous affiliations of Motoyuki Sugai include Kawasaki Medical School & Juntendo University.
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Papers
Cytotoxic necrotizing factor type 2 produced by pathogenic Escherichia coli deamidates a gln residue in the conserved G-3 domain of the rho family and preferentially inhibits the GTPase activity of RhoA and rac1.
Motoyuki Sugai,Kiyotaka Hatazaki,Akira Mogami,Hiroyuki Ohta,Sylvie Y. Pérès,Frédéric Herault,Yasuhiko Horiguchi,Minako Masuda,Yoko Ueno,Hitoshi Komatsuzawa,Hidekazu Suginaka,Eric Oswald +11 more
TL;DR: The results indicate that CNF2 and CNF1 share the same catalytic activity but have distinct substrate specificities, which may reflect their differences in toxic activity in vivo.
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Biogenesis of the Actinobacillus actinomycetemcomitans Cytolethal Distending Toxin Holotoxin
Yoko Ueno,Masaru Ohara,Toru Kawamoto,Tamaki Fujiwara,Hitoshi Komatsuzawa,Eric Oswald,Motoyuki Sugai +6 more
TL;DR: Investigation of the cell cycle G2/M specific inhibitor cytolethal distending toxin from Actinobacillus actinomycetemcomitans suggests that CDT forms a complex inside the periplasm for lipid modification where posttranslational processing of CdtA plays an important role for the efficient production of CDT holotoxin into the culture supernatant.
Prevalence of Rho-Inactivating Epidermal Cell Differentiation Inhibitor Toxins in Clinical Staphylococcus aureus Isolates
Anja Czech,Takayuki Yamaguchi,Lutz Bader,Stefan Linder,Kristina Kaminski,Motoyuki Sugai,Martin Aepfelbacher +6 more
TL;DR: Pulsed-field gel electrophoresis analysis suggested that the edin-B-positive S. aureus isolates are derived from one clone, and the edIn-C-positive isolates is derived from another clone, which suggests that toxins acting on Rho GTPases are considered to be important for bacterial virulence.
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Irsogladine maleate influences the response of gap junctional intercellular communication and IL-8 of human gingival epithelial cells following periodontopathogenic bacterial challenge.
Yuushi Uchida,Hideki Shiba,Hitoshi Komatsuzawa,Chikara Hirono,Arata Ashikaga,Tsuyoshi Fujita,Hiroyuki Kawaguchi,Motoyuki Sugai,Yoshiki Shiba,Hidemi Kurihara +9 more
TL;DR: Findings suggest that Irsogladine maleate may eliminate initial perturbation of gingival epithelial cells by regulating responses of GJIC and IL-8 to periodontopathogenic bacterial exposure.
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Distinct two-component systems in methicillin-resistant Staphylococcus aureus can change the susceptibility to antimicrobial agents
TL;DR: A battery of TCS-inactivated mutant strains of S. aureus MW2 were analysed to evaluate their possible involvement in the regulation of susceptibility to several antibacterial agents and to construct all but one TCS mutant, termed VicRK.