Morris F. White

TL;DR: Work in a transgenic mouse model in which β-cells are nearly almost completely ablated shows that adult α-cells, normally responsible for producing the peptide hormone glucagon, can be spontaneously reprogrammed to become β- cells, suggesting possible diabetes therapies involving either differentiation settings for in vitro cell production or induced regeneration in vivo.

TL;DR: Trimeprazine, its analogs, or possibly other compounds that increase IRS2 in islets and β cells without adverse systemic effects might provide mechanism-based strategies to prevent the progression of diabetes.

TL;DR: In this article, the relative roles of IRS1 and IRS2 in regulating pancreatic alpha cell function were compared using in-vivo and in vitro studies targeting insulin receptor substrate (IRS) proteins.

TL;DR: In this article, the role of hepatic transcriptional co-activator with PDZ-binding motif (TAZ) in the inhibition of glucocorticoid receptor (GR) was investigated.