Morris F. White
Boston Children's Hospital
344 Papers
5K Citations
Morris F. White is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Insulin receptor & Insulin receptor substrate. The author has an hindex of 117, co-authored 336 publications. Previous affiliations of Morris F. White include University of Vermont & Wayne State University.
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Papers
Essential role of protein kinase Cζ in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes
Mónica Arribas,Ángela M. Valverde,Deborah J. Burks,Johannes Klein,Robert V. Farese,Morris F. White,Manuel Benito +6 more
TL;DR: The results support the essential role played by PKCζ in the insulin resistance and impaired glucose uptake observed in IRS‐2‐deficient brown adipocytes and restore IRS‐ 2/PI 3‐kinase/PKCζ signalling as well as glucose uptake.
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FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance.
TL;DR: This paper showed that modestly reduced Fgf21-owing to cell-autonomous suppression by hepatic FoxO1-contributes to dysregulated metabolism in LDKO mice.
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Foxo1 in hepatic lipid metabolism.
Zhiyong Cheng,Morris F. White +1 more
TL;DR: This is the first study of its kind to evaluate the impact of repeated exposure to radiation on the immune systems of mice over a long period of time and shows clear patterns of decline in both the number of animals and the severity of the injuries sustained.
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Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance.
Amy K. Sutton,Ian E. Gonzalez,Marianna Sadagurski,Michael Rajala,Chunxia Lu,Margaret B. Allison,Jessica Adams,Martin G. Myers,Morris F. White,David P. Olson +9 more
TL;DR: This work identifies and characterize a non-OXT, non-NOS1 subpopulation of PVH and peri-PVH neurons expressing insulin-receptor substrate 4 (IRS4 PVH ) involved in energy balance control and demonstrates the sufficiency and necessity of IRS 4 PVH neurons in normal feeding and energy expenditure regulation.