Monica Spinelli
University of Padua
21 Papers
165 Citations
Monica Spinelli is an academic researcher from University of Padua. The author has contributed to research in topics: Myeloid & Acute leukemia. The author has an hindex of 14, co-authored 21 publications.
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Papers
Quantitative multiparametric immunophenotyping in acute lymphoblastic leukemia: correlation with specific genotype. I. ETV6/AML1 ALLs identification.
L De Zen,Alberto Orfao,Giovanni Cazzaniga,L Masiero,M. G. Cocito,Monica Spinelli,A Rivolta,Andrea Biondi,Luigi Zanesco,Giuseppe Basso,Giuseppe Basso +10 more
TL;DR: It is concluded that childhood precursor B-ALL carrying the t(12;21) translocation display characteristic phenotypic features which could provide a rapid, simple, sensitive and specific screening method to select for those cases that should undergo confirmatory molecular analysis.
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Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down's syndrome, revealing PRAME as a specific discriminating marker
Suzanne McElwaine,Claire Mulligan,Jürgen Groet,Monica Spinelli,Andrea Rinaldi,Gareth Denyer,Afua Adjeiwaa Mensah,S Cavani,C. Baldo,Franca Dagna-Bricarelli,Ian Hann,Giuseppe Basso,Finbarr E. Cotter,Dean Nizetic +13 more
TL;DR: Transient myeloproliferative disorder is a unique, spontaneously regressing neoplasia specific to Down's syndrome, and markers discriminating TMD from AMKL‐M7 in DS have the potential as predictive, diagnostic and therapeutic targets.
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Loss-of-function JAK3 mutations in TMD and AMKL of Down syndrome
Serena De Vita,Claire Mulligan,Suzanne McElwaine,Franca Dagna-Bricarelli,Monica Spinelli,Giuseppe Basso,Dean Nizetic,Jürgen Groet +7 more
TL;DR: It is suggested that both gain‐, and loss‐of function mutations of jak3 can be acquired in DS‐TMD/AMKL.
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The common TEL/AML1 rearrangement does not represent a frequent event in acute lymphoblastic leukaemia occuring in children with Down syndrome.
Carlo Lanza,Gisella Volpe,Guiseppe Basso,Enrico Gottardi,F Perfetto,V Cilli,Monica Spinelli,E Ricotti,Angelo Guerrasio,E Madon,G. Saglio +10 more
TL;DR: Whether the t(12;21) could give a molecular clue as to the precise basis of the etiologic association between DS and acute lymphoblastic leukemia is investigated, and the absence of the TEL/AML1 rearrangement among the 11 cases tested may be suggestive of alternative pathways involved in the pathogenesis of ALL in children with constitutional trisomy 21.
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Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia.
Giuseppe Germano,Martina Pigazzi,L. Del Giudice,M. Campo Dellorto,Monica Spinelli,Andrea Zangrando,Paolo Paolucci,Saverio Ladogana,Giuseppe Basso +8 more
TL;DR: The high expression of HOXA9 and FLT3 genes remaining genotypically stable in a leukemia throughout phenotypic switches, suggests that this leukemia may have originated as a common B/myeloid progenitors.
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