Monica Shin
McGill University
35 Papers
104 Citations
Monica Shin is an academic researcher from McGill University. The author has contributed to research in topics: Medicine & Disease. The author has an hindex of 8, co-authored 28 publications. Previous affiliations of Monica Shin include Douglas Mental Health University Institute.
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Papers
Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain
Kok Pin Ng,Tharick A. Pascoal,Sulantha Mathotaarachchi,Joseph Therriault,Min Su Kang,Monica Shin,Marie-Christine Guiot,Qi Guo,Ryuichi Harada,Robert A. Comley,Gassan Massarweh,Jean-Paul Soucy,Nobuyuki Okamura,Serge Gauthier,Pedro Rosa-Neto +14 more
TL;DR: The results indicate that the interpretation of 18F-THK5351 PET images, with respect to tau, is confounded by the high MAO-B availability across the entire brain.
Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals.
Firoza Z. Lussier,Tharick A. Pascoal,Mira Chamoun,Joseph Therriault,Cecile Tissot,Melissa Savard,Min Su Kang,Min Su Kang,Sulantha Mathotaarachchi,Andrea Lessa Benedet,Marlee Parsons,Muhammad Naveed Iqbal Qureshi,Emilie Thomas,Monica Shin,Laurie-Anne Dion,Gassan Massarweh,Gassan Massarweh,Jean-Paul Soucy,Jean-Paul Soucy,I-Huang Tsai,Paolo Vitali,Zahinoor Ismail,Pedro Rosa-Neto,Pedro Rosa-Neto,Serge Gauthier +24 more
TL;DR: This work examines the associations between MBI and Alzheimer's disease (AD) biomarkers in asymptomatic elderly individuals and finds no clear link between these biomarkers and dementia.
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Aβ-induced vulnerability propagates via the brain's default mode network.
Tharick A. Pascoal,Tharick A. Pascoal,Sulantha Mathotaarachchi,Min Su Kang,Min Su Kang,Sara Mohaddes,Monica Shin,Ah Yeon Park,Maxime Parent,Maxime Parent,Andrea Lessa Benedet,Mira Chamoun,Joseph Therriault,Heungsun Hwang,A. Claudio Cuello,Bratislav Misic,Jean-Paul Soucy,John A. D. Aston,Serge Gauthier,Pedro Rosa-Neto +19 more
TL;DR: It is found that Aβ aggregation within the brain’s default mode network leads to regional hypometabolism in distant but functionally connected brain regions, suggesting a model in which distant Aβ induces regional metabolic vulnerability, whereas the interaction between local Aβ with a vulnerable environment drives the clinical progression of dementia.
Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment
Liyong Wu,Liyong Wu,Jared Rowley,Sara Mohades,Antoine Leuzy,Marina Dauar,Monica Shin,Vladimir S. Fonov,Jianping Jia,Serge Gauthier,Pedro Rosa-Neto,Pedro Rosa-Neto +11 more
TL;DR: The present results indicate that brain metabolism remains normal despite the presence of significant amyloid accumulation in EMCI and suggest a role for anti-amyloid interventions in E MCI aiming to delay or halt the deposition of amyloids and related metabolism impairment.
White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and Alzheimer's disease.
Jared Rowley,Vladimir S. Fonov,Ona Wu,Simon Fristed Eskildsen,Dorothee Schoemaker,Liyong Wu,Liyong Wu,Sara Mohades,Monica Shin,Viviane Sziklas,Laksanun Cheewakriengkrai,Amir Shmuel,Alain Dagher,Serge Gauthier,Pedro Rosa-Neto,Pedro Rosa-Neto +15 more
TL;DR: The severity of white matter degeneration appears to be higher in advanced clinical stages, supporting the construct that these abnormalities are part of the pathophysiological processes of Alzheimer’s disease.