Mónica Martínez-Martínez
Spanish National Research Council
32 Papers
96 Citations
Mónica Martínez-Martínez is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Biology & Gut flora. The author has an hindex of 17, co-authored 31 publications.
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Papers
Estimating the success of enzyme bioprospecting through metagenomics: current status and future trends.
Manuel Ferrer,Mónica Martínez-Martínez,Rafael Bargiela,Wolfgang R. Streit,Olga V. Golyshina,Peter N. Golyshin +5 more
TL;DR: The current challenges and future actions needed before environmental enzymes can be successfully introduced into the market are suggested and estimations about the success of fine‐tuned naïve‐ and sequence‐based screening protocols for enzyme selection are provided.
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Determinants and Prediction of Esterase Substrate Promiscuity Patterns
Mónica Martínez-Martínez,Cristina Coscolín,Gerard Santiago,Jennifer Chow,Peter J. Stogios,Rafael Bargiela,Christoph Gertler,José Navarro-Fernández,Alexander Bollinger,Stephan Thies,Celia Méndez-García,Ana Popovic,Greg Brown,Tatyana N. Chernikova,Antonio García-Moyano,Gro Elin Kjæreng Bjerga,Pablo Pérez-García,Tran Hai,Mercedes V. del Pozo,Runar Stokke,Ida Helene Steen,Hong Cui,Xiaohui Xu,Boguslaw Nocek,María Alcaide,Marco A. Distaso,Victoria Mesa,Ana Isabel Pelaez,Jesús Sánchez,Patrick C. F. Buchholz,Jürgen Pleiss,Antonio Fernandez-Guerra,Antonio Fernandez-Guerra,Antonio Fernandez-Guerra,Frank Oliver Glöckner,Frank Oliver Glöckner,Olga V. Golyshina,Michail M. Yakimov,Alexei Savchenko,Karl-Erich Jaeger,Karl-Erich Jaeger,Alexander F. Yakunin,Wolfgang R. Streit,Peter N. Golyshin,Victor Guallar,Victor Guallar,Manuel Ferrer +46 more
TL;DR: An extensive analysis of the substrate spectra of 145 phylogenetically and environmentally diverse microbial esterases, when tested with 96 diverse esters, finds a structural parameter that helps rank (classify) the promiscuity level of esterase from sequence data at 94% accuracy.
Functional consequences of microbial shifts in the human gastrointestinal tract linked to antibiotic treatment and obesity.
Ester Hernández,Rafael Bargiela,María Suárez Diez,Anette Friedrichs,Ana Elena Pérez-Cobas,María José Gosalbes,Henrik Knecht,Mónica Martínez-Martínez,Jana Seifert,Martin von Bergen,Alejandro Artacho,Alicia Ruiz,Cristina Campoy,Amparo Latorre,Stephan J. Ott,Andrés Moya,Antonio Suárez,Vitor A. P. Martins dos Santos,Manuel Ferrer +18 more
TL;DR: The data and analyses provide biochemical insights into the effects of antibiotic usage on the dynamics of the GIT microbiota and pin-point presumptive links to obesity.
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Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases
David Rojo,Arancha Hevia,Rafael Bargiela,Patricia López,Adriana Cuervo,Sonia González,Ana Suárez,Borja Sánchez,Mónica Martínez-Martínez,Christian Milani,Marco Ventura,Coral Barbas,Andrés Moya,Antonio Suárez,Abelardo Margolles,Manuel Ferrer +15 more
TL;DR: A metabolome-wide scan of gut microbiota in 18 subjects with systemic lupus erythematosus and 17 healthy control subjects is described and a statistically significant difference is demonstrated between the two groups.
Rational Engineering of Multiple Active Sites in an Ester Hydrolase
Gerard Santiago,Mónica Martínez-Martínez,Sandra Alonso,Rafael Bargiela,Cristina Coscolín,Peter N. Golyshin,Victor Guallar,Manuel Ferrer +7 more
TL;DR: Converting the binding pocket into an extra catalytic active site was proven to be a successful approach to create a serine ester hydrolase with two functional reactive groups.