Monica Dentice
Brigham and Women's Hospital
5 Papers
39 Citations
Monica Dentice is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Iodothyronine deiodinase & Cancer. The author has an hindex of 4, co-authored 5 publications.
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Papers
The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
Monica Dentice,Amitabha Bandyopadhyay,Balázs Gereben,Isabelle Callebaut,Marcelo A. Christoffolete,Brian W. Kim,Sahar Nissim,Jean-Paul Mornon,Ann Marie Zavacki,Anikó Zeöld,Luciane P. Capelo,Cyntia Curcio-Morelli,Rogerio S. Ribeiro,John W. Harney,Clifford J. Tabin,Antonio C. Bianco +15 more
TL;DR: ECSWSB-1 mediates a mechanism by which 'systemic' thyroid hormone can effect local control of the Hedgehog–PTHrP negative feedback loop and thus skeletogenesis.
Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.
Brian W. Kim,Ann Marie Zavacki,Cyntia Curcio-Morelli,Monica Dentice,John W. Harney,P. Reed Larsen,Antonio C. Bianco +6 more
TL;DR: D2 ERAD in human cells proceeds via an association between UBC7 and the carboxyl region of D2, a unique mechanism for the control of thyroid hormone activation.
Suppression of HMGA2 protein synthesis could be a tool for the therapy of well differentiated liposarcomas overexpressing HMGA2
Francesca Pentimalli,Monica Dentice,Monica Fedele,G M Pierantoni,Letizia Cito,Pierlorenzo Pallante,Massimo Santoro,Giuseppe Viglietto,Paola Dal Cin,Alfredo Fusco +9 more
TL;DR: The targeting of the HMGA2 protein expression may represent a promising approach for treating the well-differentiated liposarcomas resistant to conventional therapies.
34
Patent
Methods and products for treating proliferative disorders
P. Reed Larsen,Antonio Bianco,Domenico Salvatore,Monica Dentice,Caterina Missero +4 more
- 07 May 2008
TL;DR: In this paper, the authors describe methods for treating cancer and precancerous lesions by regulating levels of thyroid hormone and/or deiodinases in the local area of cancer tissue, as well as related products and kits.
6
Patent
Procédés et produits pour traiter des troubles prolifératifs
P. Reed Larsen,Antonio Bianco,Domenico Salvatore,Monica Dentice,Caterina Missero +4 more
- 07 May 2008
TL;DR: L'invention porte sur des procedes et des produits pour traiter un cancer and des lesions precancereuses par la regulation de taux d'hormone thyroide et/ou de deiodinases dans la region locale d'un tissu cancereux.