Mona Wu
McGill University
9 Papers
2 Citations
Mona Wu is an academic researcher from McGill University. The author has contributed to research in topics: Germline & Biology. The author has an hindex of 4, co-authored 6 publications. Previous affiliations of Mona Wu include Jewish General Hospital.
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Papers
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type
Leora Witkowski,Jian Carrot-Zhang,Steffen Albrecht,Somayyeh Fahiminiya,Nancy Hamel,Eva Tomiak,David Grynspan,Emmanouil Saloustros,Javad Nadaf,Barbara Rivera,Catherine Gilpin,Ester Castellsagué,Rachel Silva-Smith,François Plourde,Mona Wu,Avi Saskin,Madeleine Arseneault,Rouzan G. Karabakhtsian,Elizabeth A. Reilly,Frederick R. Ueland,Anna Margiolaki,Kitty Pavlakis,Sharon M. Castellino,Janez Lamovec,Helen J. Mackay,Lawrence M. Roth,Thomas M. Ulbright,Tracey A Bender,Vassilis Georgoulias,Michel Longy,Andrew Berchuck,Marc Tischkowitz,Inga Nagel,Reiner Siebert,Colin J.R. Stewart,Jocelyne Arseneau,W Glenn McCluggage,Blaise A. Clarke,Yasser Riazalhosseini,Martin Hasselblatt,Jacek Majewski,William D. Foulkes +41 more
TL;DR: Findings identify alterations in SMARCA4 as the major cause of SCCOHT, which could lead to improvements in genetic counseling and new treatment approaches, and at least one germline or somatic deleterious SMarCA4 mutation in 30 of 32 cases.
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Biallelic DICER1 mutations occur in Wilms tumours
Mona Wu,Nelly Sabbaghian,Bin Xu,S. Addidou-Kalucki,Chantal Bernard,Donghui Zou,Anthony E. Reeve,Michael R. Eccles,Caroline Cole,Catherine S. Choong,Adrian Charles,T.Y. Tan,Diana M. Iglesias,Paul Goodyer,William D. Foulkes +14 more
TL;DR: This study has demonstrated that a subset of WTs exhibits two ‘hits’ in DICER1, suggesting that these mutations could be key events in the pathogenesis of these tumours.
DICER1 platform domain missense variants inhibit miRNA biogenesis and lead to tumor susceptibility
Dylan Pelletier,Anne-Laure Chong,Mona Wu,Leora Witkowski,Nelly Sabbaghian,Marc R. Fabian,William D. Foulkes +6 more
TL;DR: In this paper , the authors demonstrate that four of these Platform domain variants prevent DICER1 from producing mature miRNAs and as a result impair miRNA-mediated gene silencing.
Abstract LB-89: Germ-line and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type
Leora Witkowski,Jian Carrot-Zhang,Steffen Albrecht,Nancy Hamel,Eva Tomiak,David Grynspan,Emmanouil Saloustros,Catherine Gilpin,Rachel Silva-Smith,François Plourde,Barbara Rivera,Ester Castellsagué,Mona Wu,Somayyeh Fahiminiya,Javad Nadaf,Avi Saskin,Madeleine Arseneault,Rouzan G. Karabakhtsian,Elizabeth A. Reilly,Frederick R. Ueland,Anna Margiolaki,Kitty Pavlakis,Sharon M. Castellino,Janez Lamovec,Lawrence M. Roth,Thomas M. Ulbright,Tracey A Bender,Michel Longy,Andrew Berchuck,Marc Tischkowitz,Reiner Siebert,Inga Nagel,Vassilis Georgoulias,Colin J.R. Stewart,Glenn McCluggage,Jocelyne Arseneau,Blaise A. Clarke,Yasser Riazalhosseini,Martin Hasselblatt,Jacek Majewski,William D. Foulkes +40 more
TL;DR: Germ-line and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type and could pave the way for genetic counseling and new treatment approaches.
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