Mona Meyer
Ontario Institute for Cancer Research
13 Papers
43 Citations
Mona Meyer is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: Cytarabine & Myeloid leukemia. The author has an hindex of 8, co-authored 13 publications. Previous affiliations of Mona Meyer include University of Marburg & Martin Luther University of Halle-Wittenberg.
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Papers
Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap
Jüri Reimand,Jüri Reimand,Ruth Isserlin,Veronique Voisin,Mike Kucera,Christian Tannus-Lopes,Asha Rostamianfar,Lina Wadi,Mona Meyer,Judy M. Y. Wong,Chao Xu,Daniele Merico,Gary D. Bader +12 more
TL;DR: This protocol describes pathway enrichment analysis of gene lists from RNA-seq and other genomics experiments using g:Profiler, GSEA, Cytoscape and EnrichmentMap software, and describes innovative visualization techniques.
1.6K
Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.
Mona Meyer,Jüri Reimand,Xiaoyang Lan,Renee Head,Xueming Zhu,Michelle Kushida,Jane Bayani,Jessica C. Pressey,Anath C. Lionel,Ian D. Clarke,Michael D. Cusimano,Jeremy A. Squire,Stephen W. Scherer,Mark Bernstein,Melanie A. Woodin,Gary D. Bader,Peter B. Dirks +16 more
TL;DR: It is predicted that integration of functional and genomic analysis at a clonal level will be essential for understanding evolution and therapeutic resistance of human cancer, and will lead to the discovery of novel driver mechanisms and clone-specific cancer treatment.
387
Impact of outdated gene annotations on pathway enrichment analysis
Lina Wadi,Mona Meyer,Joel Weiser,Lincoln D. Stein,Lincoln D. Stein,Jüri Reimand,Jüri Reimand +6 more
TL;DR: It is found that the use of outdated resources has strongly affected practical genomic analysis and recent literature: 67% of ~3,900 publications in 2015 referenced outdated software that captured only 26% of biological processes and pathways identified using current resources.
134
Oncogenic RAS Enables DNA Damage- and p53-Dependent Differentiation of Acute Myeloid Leukemia Cells in Response to Chemotherapy
Mona Meyer,Daniela Rübsamen,Robert K. Slany,Thomas Illmer,Kathleen Stabla,Petra Roth,Thorsten Stiewe,Martin Eilers,Andreas Neubauer +8 more
TL;DR: It is shown that oncogenic RAS synergizes with cytotoxic agents such as cytarabine in activation of DNA damage checkpoints, resulting in a p53-dependent genetic program that reduces clonogenicity and increases myeloid differentiation.
Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates
Raghuveera Kumar Goel,Mona Meyer,Marta Paczkowska,Jüri Reimand,Jüri Reimand,Frederick S. Vizeacoumar,Franco J. Vizeacoumar,TuKiet T. Lam,Kiven Erique Lukong +8 more
TL;DR: Serine/threonine phosphorylation dynamics as important secondary events of the SRMS-regulated phosphoproteome with implications in the regulation of cellular and biological processes are identified.