Compositions, kits and methods for assessing the prognosis of idiopathic pulmonary fibrosis in patients are provided In addition, compositions, kits and methods for diagnosing subtypes of idiopathic pulmonary fibrosis are provided Also provided are methods for treating idiopathic pulmonary fibrosis

Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis

Disclosed are methods for preventing, treating, or reducing symptoms of a disorder involving the autotaxin (ATX) pathway. In one embodiment, the method features administering to a mammal a sufficient amount of an autotaxin (ATX) or lysophosphatidic acid (LPA) signaling inhibitor, to prevent, treat or reduce symptoms of an inflammatory disorder, autoimmune disorder, fibrosis or malignancy of the lung. Further disclosed are methods for diagnosing an autotaxin-related disorder as well as kits for performing the methods of the invention.

Autotaxin pathway modulation and uses thereof

Provided herein are novel biomarkers for the identification, prediction or monitoring of fibrotic pulmonary diseases (e.g. idiopathic pulmonary fibrosis (IPF)). The biomarkers provided herein may further be used for therapeutic treatment of IPF.

Proteomic ipf markers

A method is provided along with related reagent kits for aiding the diagnosis of IPF or other interstitial lung diseases, as well as for potential monitoring of disease progression or therapeutic response to treatment.

Mmp activation peptide detection in biological samples

Biomarkers, kits, and diagnostic and treatment methods for idiopathic pulmonary fibrosis are provided.

Biomarkers for idiopathic pulmonary fibrosis

The present invention relates to the discovery that of a panel of serum or plasma markers may be used to diagnose Idiopathic Pulmonary Fibrosis (“IPF”) and distinguish this condition from other lung ailments. It further relates to the identification of markers associated with IPF disease progression.

Marker panels for idiopathic pulmonary fibrosis diagnosis and evaluation

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Marker panels for idiopathic pulmonary fibrosis diagnosis and evaluation