Moira Sauane
City University of New York
45 Papers
1.2K Citations
Moira Sauane is an academic researcher from City University of New York. The author has contributed to research in topics: Apoptosis & Melanoma. The author has an hindex of 25, co-authored 43 publications. Previous affiliations of Moira Sauane include Fundación Instituto Leloir & Columbia University Medical Center.
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Papers
mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine.
Pankaj Gupta,Zao-Zhong Su,Irina V. Lebedeva,Devanand Sarkar,Moira Sauane,Luni Emdad,Michael A. Bachelor,Steven Grant,David T. Curiel,Paul Dent,Paul B. Fisher +10 more
TL;DR: Current understanding of the diverse activities and properties of this novel cytokine, mda-7/IL-24, with potential to become a prominent gene therapy for cancer are highlighted.
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Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.
Zao-Zhong Su,Irina V. Lebedeva,Devanand Sarkar,Rahul V. Gopalkrishnan,Moira Sauane,Carter Sigmon,Adly Yacoub,Kristoffer Valerie,Paul Dent,Paul B. Fisher +9 more
TL;DR: The present findings suggest that Ad.mda-7 may, in many instances, prove more beneficial for the gene-based therapy of malignant gliomas than administration of wild-type p53.
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MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine.
Moira Sauane,Rahul V. Gopalkrishnan,Devanand Sarkar,Zao Zhong Su,Irina V. Lebedeva,Paul Dent,Sidney Pestka,Paul B. Fisher +7 more
TL;DR: A notable property of MDA-7/IL-24 is its ability to induce apoptosis in a large spectrum of human cancer derived cell lines, in mouse xenografts and upon intratumoral injection in human tumors (phase I clinical trials).
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Unique aspects of mda-7/IL-24 antitumor bystander activity : establishing a role for secretion of MDA-7/IL-24 protein by normal cells
Zhao-zhong Su,Luni Emdad,Moira Sauane,Irina V. Lebedeva,Devanand Sarkar,Pankaj Gupta,C. David James,Aaron Randolph,Kirstoffer Valerie,Mark R. Walter,Paul Dent,Paul B. Fisher +11 more
TL;DR: The present studies provide definitive evidence that secreted mda-7/IL-24 from normal cells can induce direct antitumor and radiation-enhancing effects that are dependent on the presence of canonical receptors for this cytokine on tumor cells.
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mda-7/IL-24: exploiting cancer's Achilles' heel.
Irina V. Lebedeva,Moira Sauane,Rahul V. Gopalkrishnan,Devanand Sarkar,Zhao Zhong Su,Pankaj Gupta,John Nemunaitis,Casey Cunningham,Adly Yacoub,Paul Dent,Paul B. Fisher +10 more
TL;DR: It is heartening to note that mda-7/IL-24 has made a methodical and progressive journey, from an unidentified novel sequence with little homology to known genes at its time of isolation to currently having the status of a molecule belonging to the IL-10-related family of cytokines, with considerable cancer gene therapeutic potential.
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