Mohyee E. Eldefrawi
University of Maryland, College Park
5 Papers
42 Citations
Mohyee E. Eldefrawi is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: GABAA receptor & Biopanning. The author has an hindex of 4, co-authored 5 publications.
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Papers
Acetylcholinesterase fiber-optic biosensor for detection of anticholinesterases.
TL;DR: An optical sensor for anticholinesterases (AntiChEs) was constructed by immobilizing fluorescein isothiocyanate-tagged eel electric organ acetylcholinesTERase (AChE) on quartz fibers and monitoring enzyme activity, which shows potential adaptability to field use.
92
Directing antigen specificity towards botulinum neurotoxin with combinatorial phage display libraries
Peter Emanuel,Thomas O'Brien,James Burans,Bibhuti R. DasGupta,James J. Valdes,Mohyee E. Eldefrawi +5 more
TL;DR: The production of recombinant immunoglobulin libraries in bacteria allows for a more controlled selection of antibody specificity and can be used in circumstances where hybridoma fusions are unable to isolate rare clones with the desired epitope specificity.
36
The GABA Receptor and the Action of Tremorgenic Mycotoxins
Mohyee E. Eldefrawi,Daniel B. Gant,Amira T. Eldefrawi +2 more
- 01 Jan 1990
TL;DR: The gamma-aminobutyric acid (GABA) receptor is the major inhibitory receptor in vertebrate and invertebrate brains and is studied biochemically by the characteristics and specificity or its binding of TBPS and also by monitoring its function in vitro.
7
Reusable Fiber Optic Biosensors for Detection of Drugs and Toxicants
Mohyee E. Eldefrawi,Amira T. Eldefrawi,Nabil A. Anis,James J. Valdes +3 more
- 01 Jan 1993
TL;DR: Use of fluorescein derivatives of specific analytes, that are bound reversibly by biological sensing elements (e.g. receptors or antibodies), proved to be a successful strategy for fiber optic biosensors.
1
Action of Organophosphates on GABAA Receptor and Voltage-Dependent Chloride Channels
TL;DR: Although the voltage-dependent chloride channel and/or GABAA receptor are not primary targets for organophosphate anticholinesterases and flame retardants, it is suggested that the inhibition of these two proteins by certain organoph phosphates may contribute to their toxicities.