Mohan Wang
Huazhong Agricultural University
6 Papers
Mohan Wang is an academic researcher from Huazhong Agricultural University. The author has contributed to research in topics: Gene & Protein kinase R. The author has an hindex of 2, co-authored 3 publications.
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Papers
The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/ MDA5 activation
Zhen Ding,Liurong Fang,Shuangling Yuan,Ling Zhao,Xunlei Wang,Siwen Long,Mohan Wang,Dang Wang,Mohamed F. Foda,Shaobo Xiao +9 more
TL;DR: It is confirmed that both MHV and SARS-CoV N proteins can perturb the function of cellular PACT to circumvent the innate antiviral response, however, this strategy does not appear to be used by all CoVs N proteins.
Porcine deltacoronavirus nucleocapsid protein antagonizes IFN-β production by impairing dsRNA and PACT binding to RIG-I.
Jun Chen,Puxian Fang,Mohan Wang,Qi Peng,Jie Ren,Dang Wang,Guiqing Peng,Liurong Fang,Shaobo Xiao,Zhen Ding +9 more
TL;DR: It is found that PDCoV nucleocapsid (N) protein, the most abundant viral structural protein, suppressed Sendai virus (SEV)-induced IFN-β production and transcription factor IRF3 activation, but did not blockIFN- β production induced by overexpressing RIG-I/MDA5.
Analysis and Experimental Validation of Rheumatoid Arthritis Innate Immunity Gene CYFIP2 and Pan-Cancer
Zhenyu Zhao,Shaojie He,Xinchen Yu,Xiaofeng Lai,S.K. Tang,El Akkawi Mariya M.,Mohan Wang,Hai Yan,Xingqi Huang,Shan Zeng,Dingsheng Zha +10 more
TL;DR: The results of the pan-cancer analysis showed that CYFIP2 was closely related to the prognosis of patients with various tumors, the degree of immune cell infiltration, as well as TMB, MSI, and other indicators, suggesting that this gene may be a potential intervention target for human diseases including RA and tumors.
CLP1 is a Prognosis-Related Biomarker and Correlates With Immune Infiltrates in Rheumatoid Arthritis
Zhenyu Zhao,Shaojie He,S.K. Tang,Xiaofeng Lai,Jie Ren,Xinchen Yu,Jinhua Lin,Mohan Wang,Mariya M. El Akkawi,Shan Zeng,Dingsheng Zha +10 more
TL;DR: CLP1 may play a non-negligible role in the onset and development of RA by altering immune cell infiltration, and it is predicted to represent a novel target for RA clinical diagnosis and therapy.
6
DEAD-box RNA helicase 18 disrupts IRF3-binding to the interferon-β promoter
TL;DR: In this article, the authors identified DEAD-box RNA helicase 18 (DDX18) as an important negative regulator of interferon regulatory factor 3 (IRF3) to the IFN-β promoter region in the nucleus.