Mohammad Khalil
University of Erlangen-Nuremberg
9 Papers
14 Citations
Mohammad Khalil is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Colitis & Internal medicine. The author has an hindex of 6, co-authored 8 publications.
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Papers
The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons
Matthias Engel,Mohammad Khalil,Sonja M. Mueller-Tribbensee,Christoph Becker,Winfried Neuhuber,Markus F. Neurath,Peter W. Reeh +6 more
TL;DR: The spatial correlation among increased colonic innervation density, TRPV1 receptor expression, stimulated SP release, and colitis severity suggested that TRPv1/SP-expressing sensory neurons should be considered as a therapeutic target in human ulcerative colitis.
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Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production.
Mohammad Khalil,Alexandru Babes,R Lakra,S Försch,Peter W. Reeh,Stefan Wirtz,Christoph Becker,Markus F. Neurath,Matthias Engel +8 more
TL;DR: It is shown that the cold-sensing TR PM8 has an unexpected role in innate immunity and novel TRPM8-based options for immunomodulatory intervention are suggested.
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Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis
Matthias Engel,Mohammad Khalil,Norbert Siklosi,Sonja M. Mueller-Tribbensee,Winfried Neuhuber,Markus F. Neurath,Christoph Becker,Peter W. Reeh +7 more
TL;DR: It is demonstrated that the neuropeptides CGRP and SP exert opposing effects in oxazolone colitis and provide further evidence for a prominent neuroimmune association in the gut.
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Highlights in inflammatory bowel disease – from bench to bedside
TL;DR: The current knowledge on the epidemiology and genetics of IBD is summarized, and new pathogenetic insights as well as promising future therapeutic options are described.
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Dual opposing actions of STW 5 on TRP receptors mediate neuronal desensitisation in vitro.
Mohammad Khalil,Z. Zhang,Heba Abdel-Aziz,Sabine Rabini,Ramy M. Ammar,Ramy M. Ammar,Peter W. Reeh,Matthias Engel +7 more
TL;DR: Repeated exposure to STW 5 induced desensitisation of sensory neurons and may ultimately contribute to its clinical efficacy against sensory-related symptoms in patients with FGID.
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